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462Episodes
Category: Science

A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.

Episode 458 - Molecular methods to fight fungi and bacteria

November 22, 2021

There's a public health crisis looming beyond the pandemic. Researchers across the world are working to stop the next public health disaster - the rise of antibiotic resistance. We rely on antibiotics to treat various disease but their effectiveness wanes as bacteria builds its resistance. How do we keep track of the changes in bacteria's resistance to antibiotics? What do bird droppings in Cambridge tell us about antibiotic resistance? Developing new antibiotics is tricky, what part of bacteria do you target? Is it better to have a simple molecule or a complex one when tackling bacteria? Bursting the bacteria cell is one way to defeat but its even better to break their building blocks. Fungal infections are growing more resistant to treatment. How can we devleop new categories of anti-fungal treatments?
References

  1. Joana G. C. Rodrigues, Harisree P. Nair, Christopher O'Kane, Caray A. Walker. Prevalence of multidrug resistance in Pseudomonas spp. isolated from wild bird feces in an urban aquatic environmentEcology and Evolution, 2021; 11 (20): 14303 DOI: 10.1002/ece3.8146
  2. Elisabeth Reithuber, Torbjörn Wixe, Kevin C. Ludwig, Anna Müller, Hanna Uvell, Fabian Grein, Anders E. G. Lindgren, Sandra Muschiol, Priyanka Nannapaneni, Anna Eriksson, Tanja Schneider, Staffan Normark, Birgitta Henriques-Normark, Fredrik Almqvist, Peter Mellroth. THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediatesProceedings of the National Academy of Sciences, 2021; 118 (47): e2108244118 DOI: 10.1073/pnas.2108244118
  3. Christian DeJarnette, Chris J. Meyer, Alexander R. Jenner, Arielle Butts, Tracy Peters, Martin N. Cheramie, Gregory A. Phelps, Nicole A. Vita, Victoria C. Loudon-Hossler, Richard E. Lee, Glen E. Palmer. Identification of Inhibitors of Fungal Fatty Acid BiosynthesisACS Infectious Diseases, 2021; DOI: 10.1021/acsinfecdis.1c00404