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3Episodes
Category: Science

A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.

Episode 354 - Safer pacemakers and mini machines inside our cells

November 25, 2019

Our bodies are filled with molecular and cellular machines, pumping, spinning and moving. How do tiny single molecules pump sodium ions across a cell? What is the connection between a single molecule pump and cells producing electricity? How can a single molecule pump be more efficient than our modern ones? How do we make pacemakers safer? Overtime a pacemaker grows to become part of the heart fibre. How do we make pacemakers less likely to be overgrown and easier to replace? 

References: 

  1. Tatsuya Iida, Yoshihiro Minagawa, Hiroshi Ueno, Fumihiro Kawai, Takeshi Murata, Ryota Iino. Single-molecule analysis reveals rotational substeps and chemo-mechanical coupling scheme of Enterococcus hirae V1-ATPaseJournal of Biological Chemistry, 2019; 294 (45): 17017 DOI: 10.1074/jbc.RA119.008947
  2. Francesco Robotti, Ita Sterner, Simone Bottan, Josep M. Monné Rodríguez, Giovanni Pellegrini, Tanja Schmidt, Volkmar Falk, Dimos Poulikakos, Aldo Ferrari, Christoph Starck. Microengineered biosynthesized cellulose as anti-fibrotic in vivo protection for cardiac implantable electronic devicesBiomaterials, 2020; 229: 119583 DOI: 10.1016/j.biomaterials.2019.119583