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3Episodes
Category: Science & Medicine

A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.

Episode 297 - Antibiotic superweapons - hunter killer cells, dream teams and evolutionary history

October 22, 2018
00:0000:00

Making new treatments often starts by finding out just what building blocks you have. But what if you could use the blocks with whole new sets? What if you could see how the blocks changed between owners? What about making your own brand new blocks? When fighting bacteria, we need every tool we can get. This week we find out about some great ways to take the fight back to bacteria in new and interesting ways from artificial cells, or new combinations of treatments, even to tracking the way bacteria changes over aeons.

References:

  1. Emily J. Richardson, Rodrigo Bacigalupe, Ewan M. Harrison, Lucy A. Weinert, Samantha Lycett, Manouk Vrieling, Kirsty Robb, Paul A. Hoskisson, Matthew T. G. Holden, Edward J. Feil, Gavin K. Paterson, Steven Y. C. Tong, Adebayo Shittu, Willem van Wamel, David M. Aanensen, Julian Parkhill, Sharon J. Peacock, Jukka Corander, Mark Holmes, J. Ross Fitzgerald. Gene exchange drives the ecological success of a multi-host bacterial pathogen. Nature Ecology & Evolution, 2018; 2 (9): 1468 DOI: 10.1038/s41559-018-0617-0
  2. Elif Tekin, Cynthia White, Tina Manzhu Kang, Nina Singh, Mauricio Cruz-Loya, Robert Damoiseaux, Van M. Savage, Pamela J. Yeh. Prevalence and patterns of higher-order drug interactions in Escherichia coli. npj Systems Biology and Applications, 2018; 4 (1) DOI: 10.1038/s41540-018-0069-9
  3. Yunfeng Ding, Luis E. Contreras-Llano, Eliza Morris, Michelle Mao, Cheemeng Tan. Minimizing Context Dependency of Gene Networks Using Artificial Cells. ACS Applied Materials & Interfaces, 2018; DOI: 10.1021/acsami.8b10029