Episodes
Wednesday Oct 04, 2023
Episode 552 - Talking to plants and how a jellyfish learns
Wednesday Oct 04, 2023
Wednesday Oct 04, 2023
How does a jellyfish manage to see and learn without a large central brain? Like the Scarecrow of Oz, jellyfish are a without a brain but are still able to learn and do great feats. How does the nervous system of a jellyfish learn to dodge and avoid obstacles without a big brain? Plants respond to light, but is it possible to communicate with them about upcoming dangers?
- Jan Bielecki, Sofie Katrine Dam Nielsen, Gösta Nachman, Anders Garm. Associative learning in the box jellyfish Tripedalia cystophora. Current Biology, 2023; DOI: 10.1016/j.cub.2023.08.056
- Bo Larsen, Roberto Hofmann, Ines S. Camacho, Richard W. Clarke, J Clark Lagarias, Alex R. Jones, Alexander M. Jones. Highlighter: An optogenetic system for high-resolution gene expression control in plants. PLOS Biology, 2023; 21 (9): e3002303 DOI: 10.1371/journal.pbio.3002303
Thursday Aug 17, 2023
Episode 547 - Concussions - How long do you really have to wait?
Thursday Aug 17, 2023
Thursday Aug 17, 2023
How long do you really have to wait after a concussion? Athletes are always keen to get back in the game after a head knock, but how long do they really need to wait? When trying to assess and track a concussion getting hard data is difficult. Using special headbands and measuring the pulse of the brain you can get an insight into concussion recovery. Concussion symptoms can disappear long before the brain has truly recovered. If you are slowly recovering fro a concussion how long will you need to wait?
- Cathra Halabi, Lynda Norton, Kevin Norton, Wade S. Smith. Headpulse Biometric Measures Following Concussion in Young Adult Athletes. JAMA Network Open, 2023; 6 (8): e2328633 DOI: 10.1001/jamanetworkopen.2023.28633
- Thomas Walker McAllister, Steven P Broglio, Barry P Katz, Susan M Perkins, Michelle LaPradd, Wenxian Zhou, Michael A McCrea. Characteristics and Outcomes of Athletes With Slow Recovery From Sport-Related Concussion: A CARE Consortium Study. Neurology, 2023; 10.1212/WNL.0000000000206853 DOI: 10.1212/WNL.0000000000206853
Monday Apr 10, 2023
Episode 529 - Listening in on conversations inside your body
Monday Apr 10, 2023
Monday Apr 10, 2023
Your body is constantly communicating about what's happening outside and inside of it, but how can we listen in. When your immune system is responding to a virus, or a wound is healing, there are lots of signals to decode if only we could hear them. By amplifying the signals inside your body with special folding DNA and transistors we can understand how our body responds. The brain's neural networks are a treasure trove of information if we're able to blend in and listen. Using a microbot you can get precise information from on inside in the brain rather than relying on external information.
- Xudong Ji, Xuanyi Lin, Jonathan Rivnay. Organic electrochemical transistors as on-site signal amplifiers for electrochemical aptamer-based sensing. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-37402-2
- Eunhee Kim, Sungwoong Jeon, Yoon‐Sil Yang, Chaewon Jin, Jin‐young Kim, Yong‐Seok Oh, Jong‐Cheol Rah, Hongsoo Choi. A Neurospheroid‐Based Microrobot for Targeted Neural Connections in a Hippocampal Slice. Advanced Materials, 2023; 35 (13) DOI: 10.1002/adma.202208747
Thursday Apr 06, 2023
Episode 528 - How our senses pass information to our brains
Thursday Apr 06, 2023
Thursday Apr 06, 2023
How does your body pass information along to your brain? The thalamus connects those sensory inputs back to your cerebral cortex but it's a lot sparser than you'd think. The synapses that link your senses to your cortex are often weak and rare, but their diversity gives them a boost. Lots of diverse synapses with different strengths help you perceive the world more clearly. Do both your eyes get equally treated by your brain?
- Aygul Balcioglu, Rebecca Gillani, Michael Doron, Kendyll Burnell, Taeyun Ku, Alev Erisir, Kwanghun Chung, Idan Segev, Elly Nedivi. Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their ‘readout’ of visual input. Nature Neuroscience, 2023; DOI: 10.1038/s41593-022-01253-9
- Joel Bauer, Simon Weiler, Martin H.P. Fernholz, David Laubender, Volker Scheuss, Mark Hübener, Tobias Bonhoeffer, Tobias Rose. Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse. Neuron, 2021; DOI: 10.1016/j.neuron.2021.05.036
Monday Jan 09, 2023
Episode 517 - How our body senses and interacts with the world
Monday Jan 09, 2023
Monday Jan 09, 2023
Understanding how our body senses and interacts with the world. Scientists are only now beginning to understand how our body senses the world, hence the '21 Nobel Prizes. This Nobel prize wining research helped others find a connection between the gut and our sense of touch. Internal organ pain can be crippling and require side effect laden treatments. How do organs like the gut detect and transmit pain signals? The same mechanism to detect soft touch is used by your organs to send pain signals. How does our body precisely control temperature? What region of the brain measures and control what temperature to set itself to?
- Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, Hongzhen Hu. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron, 2022; DOI: 10.1016/j.neuron.2022.11.015
- Yoshiko Nakamura, Takaki Yahiro, Akihiro Fukushima, Naoya Kataoka, Hiroyuki Hioki, Kazuhiro Nakamura. Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling. Science Advances, 2022; 8 (51) DOI: 10.1126/sciadv.add5463
Monday Nov 28, 2022
Episode 511 - How the earliest brains developed and handle touch
Monday Nov 28, 2022
Monday Nov 28, 2022
Peering into the history of brains with some amazing tiny fossils. How did the earliest brains develop? Is a head just an extension of a segmented body or something else entirely? How did the first brains and nervous systems evolve in arthropods. How does your body process the sense of touch? The faintest sensations of touch are handled by specialist cells in your spinal cord. How do your brain stem and spinal cord help your body process the senses?
- Nicholas J. Strausfeld, Xianguang Hou, Marcel E. Sayre, Frank Hirth. The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains. Science, 2022; 378 (6622): 905 DOI: 10.1126/science.abn6264
- Turecek, J., Lehnert, B.P. & Ginty, D.D. The encoding of touch by somatotopically aligned dorsal column subdivisions. Nature, 2022 DOI: 10.1038/s41586-022-05470-x
- Anda M. Chirila, Genelle Rankin, Shih-Yi Tseng, Alan J. Emanuel, Carmine L. Chavez-Martinez, Dawei Zhang, Christopher D. Harvey, David D. Ginty. Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain. Cell, 2022; 185 (24): 4541 DOI: 10.1016/j.cell.2022.10.012
Monday Jul 25, 2022
Episode 493 - Pleasant memories of sound and music relieving pain
Monday Jul 25, 2022
Monday Jul 25, 2022
There are plenty of tales of music soothing wild beasts, but is there actually a link between music and pain relief? How did researchers quantitatively study the soothing powers of music? What's better for blocking out pain ; Classical music, discordant arrangements or white noise? How does sound dull the effect of pain in mice? Just how good is a bat's auditory long term memory? can you train a bat to recognize the sound of a tasty treat? How do bats process and associate sounds with food?
- Wenjie Zhou, Chonghuan Ye, Haitao Wang, Yu Mao, Weijia Zhang, An Liu, Chen-Ling Yang, Tianming Li, Lauren Hayashi, Wan Zhao, Lin Chen, Yuanyuan Liu, Wenjuan Tao, Zhi Zhang. Sound induces analgesia through corticothalamic circuits. Science, 2022; 377 (6602): 198 DOI: 10.1126/science.abn4663
- M. May Dixon, Patricia L. Jones, Michael J. Ryan, Gerald G. Carter, Rachel A. Page. Long-term memory in frog-eating bats. Current Biology, 2022; 32 (12): R557 DOI: 10.1016/j.cub.2022.05.031
Tuesday Jun 07, 2022
Episode 486 - Bypassing the brains defences for treatment
Tuesday Jun 07, 2022
Tuesday Jun 07, 2022
The brain is incredibly important and needs to be protected by your body but this also makes it hard to treat. Brain tumours can be stubborn to root out because many treatments are blocked by the blood brain barrier. The blood brain barrier blocks many cancer treatments, but with the right disguise and nano coating cancer treatments can sneak past. Brain tumours can block the immune system from functioning, but sneaking through the right treatment can help the immune system fight back. Traumatic brain injury and subsequent inflammation can lead to significant damage, and normal anti-inflammatory methods are blocked by the blood brain barrier. If you can't sneak anti-inflammatories through the blood brain barrier, why not just boost their production locally? T Cells can fight back against inflammation after a traumatic brain injury if there's enough food for them to thrive on.
- Yshii, L., Pasciuto, E., Bielefeld, P. et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol, 2022 DOI: 10.1038/s41590-022-01208-z
- Mahmoud S. Alghamri, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Ayman Taher, Rohit Thalla, Brandon L. McClellan, Maria L. Varela, Svetlana M. Stamatovic, Gabriela Martinez-Revollar, Anuska V. Andjelkovic, Jason V. Gregory, Padma Kadiyala, Alexandra Calinescu, Jennifer A. Jiménez, April A. Apfelbaum, Elizabeth R. Lawlor, Stephen Carney, Andrea Comba, Syed Mohd Faisal, Marcus Barissi, Marta B. Edwards, Henry Appelman, Yilun Sun, Jingyao Gan, Rose Ackermann, Anna Schwendeman, Marianela Candolfi, Michael R. Olin, Joerg Lahann, Pedro R. Lowenstein, Maria G. Castro. Systemic Delivery of an Adjuvant CXCR4–CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy. ACS Nano, 2022; DOI: 10.1021/acsnano.1c07492
Monday Nov 08, 2021
Episode 456 - Responding rapidly to bad smells
Monday Nov 08, 2021
Monday Nov 08, 2021
How does our brain filter and process all those smells? Our brain has a lot of dedicated space for smells, but knowing which is which is tricky. How does our brain respond so quickly to bad smells? We will move out of the way of a bad smell fast. In under half a second you brain can detect and move away from a bad smell. Why are our brains hard wired to detect and react to the smell of caramel? Furaneol gives off a caramel like smell and is found in fruits and even bread. Why does our brain dedicate space to it? What is better at waking you up - a good smell or a bad smell? How do brains process smells even whens sleeping?
- Behzad Iravani, Martin Schaefer, Donald A. Wilson, Artin Arshamian, Johan N. Lundström. The human olfactory bulb processes odor valence representation and cues motor avoidance behavior. Proceedings of the National Academy of Sciences, 2021; 118 (42): e2101209118 DOI: 10.1073/pnas.2101209118
- Franziska Haag, Sandra Hoffmann, Dietmar Krautwurst. Key Food Furanones Furaneol and Sotolone Specifically Activate Distinct Odorant Receptors. Journal of Agricultural and Food Chemistry, 2021; 69 (37): 10999 DOI: 10.1021/acs.jafc.1c03314
- Alice S. French, Quentin Geissmann, Esteban J. Beckwith, Giorgio F. Gilestro. Sensory processing during sleep in Drosophila melanogaster. Nature, 2021; DOI: 10.1038/s41586-021-03954-w
Monday Aug 30, 2021
Episode 446 - Brains and Guts connected in surprising ways
Monday Aug 30, 2021
Monday Aug 30, 2021
Your brain and gut are connected in surprising ways. Inside your GI tract is a surprisingly complex nervous system. Your GI tract has it's own nervous system which is more like the spine than other organs. How does your GI tract differ from other soft hollow organs? The connection between gut microbiomes and brains is clear, but not well understood. Certain microbes can cause neurodegeneration in brains just as bad as a poor diet and no oxygen. How can we stop brains copy and pasting toxic byproducts across our brains? Proteins keep our brains in check and prevent build up of toxic byproducts, but this can be used to put the brakes on neurodegeneration.
References:
- Nick J. Spencer, Lee Travis, Lukasz Wiklendt, Marcello Costa, Timothy J. Hibberd, Simon J. Brookes, Phil Dinning, Hongzhen Hu, David A. Wattchow, Julian Sorensen. Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice. Communications Biology, 2021; 4 (1) DOI: 10.1038/s42003-021-02485-4
- Christine A. Olson, Alonso J. Iñiguez, Grace E. Yang, Ping Fang, Geoffrey N. Pronovost, Kelly G. Jameson, Tomiko K. Rendon, Jorge Paramo, Jacob T. Barlow, Rustem F. Ismagilov, Elaine Y. Hsiao. Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia. Cell Host & Microbe, 2021; DOI: 10.1016/j.chom.2021.07.004
- Chingakham Ranjit Singh, M. Rebecca Glineburg, Chelsea Moore, Naoki Tani, Rahul Jaiswal, Ye Zou, Eric Aube, Sarah Gillaspie, Mackenzie Thornton, Ariana Cecil, Madelyn Hilgers, Azuma Takasu, Izumi Asano, Masayo Asano, Carlos R. Escalante, Akira Nakamura, Peter K. Todd, Katsura Asano. Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism. Cell Reports, 2021; 36 (2): 109376 DOI: 10.1016/j.celrep.2021.109376
Monday Jul 26, 2021
Episode 441 - Augmenting the human body to keep it safe
Monday Jul 26, 2021
Monday Jul 26, 2021
Using technology and tools to make the human body safer. How can we use exoskeletons to keep people safe? Does using a tool like an exoskeleton automatically make a task easier? How can technology that augments bodys hinder when trying to help? How can we keep our head safer during a collision. Countless people rely on bicycles for safe and green transport, but how do we make it safer? Bicycle helmets are a simple tool for helping save lives, but can they be made even safer with new materials?
- Yibo Zhu, Eric B. Weston, Ranjana K. Mehta, William S. Marras. Neural and biomechanical tradeoffs associated with human-exoskeleton interactions. Applied Ergonomics, 2021; 96: 103494 DOI: 10.1016/j.apergo.2021.103494
- Karl A Zimmerman, Etienne Laverse, Ravjeet Samra, Maria Yanez Lopez, Amy E Jolly, Niall J Bourke, Neil S N Graham, Maneesh C Patel, John Hardy, Simon Kemp, Huw R Morris, David J Sharp. White matter abnormalities in active elite adult rugby players. Brain Communications, 2021; 3 (3) DOI: 10.1093/braincomms/fcab133
Monday May 31, 2021
Episode 433 - Prioritizing memories and filtering noise
Monday May 31, 2021
Monday May 31, 2021
How does your brain decide what's important to remember? You're constantly bombarded with info so how does your brain filter it all? Do memories change over time? Do certain details stand out more in our memories over time? What details can get lost in our memories over time? How does you brain know if it's worth 'saving' that picture you've seen. How does your brain filter out and only store the important stuff.
- Julia Lifanov, Juan Linde-Domingo, Maria Wimber. Feature-specific reaction times reveal a semanticisation of memories over time and with repeated remembering. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-23288-5
- Vahid Mehrpour, Travis Meyer, Eero P. Simoncelli, Nicole C. Rust. Pinpointing the neural signatures of single-exposure visual recognition memory. Proceedings of the National Academy of Sciences, 2021; 118 (18): e2021660118 DOI: 10.1073/pnas.2021660118
Monday Apr 19, 2021
Episode 427 - RNA protecting your brain
Monday Apr 19, 2021
Monday Apr 19, 2021
How does RNA work to protect your brain and keep it safe after a traumatic event? Micro RNA can play an important role in healthy brain development. Without key micro RNA, the development of the brain can run out of control. Without key microRNA, your can develop neurodevelopmental disorders. Without oxygen your neurons starve, so how can you protect them? How can you use mRNA to make neurons more resilient and recover after a lack of oxygen? Getting proteins across the blood brain barrier is tricky, so can they be snuck in via mRNA? Using mRNA, you can produce proteins to add brain recovery right where they're needed most.
Reference:
- Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Hume Stroud, Jeremy M. Simon, Travis S. Ptacek, Matthew V. Beck, Cornelius Flowers, Jiami Guo, Charlotte Plestant, Jie Liang, C. Lisa Kurtz, Matt Kanke, Scott M. Hammond, You-Wen He, E.S. Anton, Praveen Sethupathy, Sheryl S. Moy, Michael E. Greenberg, Mohanish Deshmukh. MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation. Cell Reports, 2021; 35 (1): 108946 DOI: 10.1016/j.celrep.2021.108946
- Merlin Crossley,Dean of Science and Professor of Molecular Biology. (2021, April 09). Explainer: What is rna? Retrieved April 13, 2021, from https://theconversation.com/explainer-what-is-rna-15169
- Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials, 2021; 270: 120681 DOI: 10.1016/j.biomaterials.2021.120681
Monday Mar 01, 2021
Monday Mar 01, 2021
Slime with memories, and 3d printed materials to repair damaged neurons. How can a slime form memories? Where does it store them? What is the largest single cell organism and how does it remember things? How can you store memories in an interconnected series of tubes? How can you use 3D printed self assembling materials to help regrow damaged neurons?
- Mirna Kramar, Karen Alim. Encoding memory in tube diameter hierarchy of living flow network. Proceedings of the National Academy of Sciences, 2021; 118 (10): e2007815118 DOI: 10.1073/pnas.2007815118
- Karen Alim, Natalie Andrew, Anne Pringle, Michael P. Brenner, Mechanism of signal propagation in P. polycephalum, Proceedings of the National Academy of Sciences May 2017, 114 (20) 5136-5141; DOI: 10.1073/pnas.1618114114
- Alexandra N. Edelbrock, Tristan D. Clemons, Stacey M. Chin, Joshua J. W. Roan, Eric P. Bruckner, Zaida Álvarez, Jack F. Edelbrock, Kristen S. Wek, Samuel I. Stupp. Superstructured Biomaterials Formed by Exchange Dynamics and Host–Guest Interactions in Supramolecular Polymers. Advanced Science, 2021; 2004042 DOI: 10.1002/advs.202004042
Monday Dec 28, 2020
Episode 411 - Lightning fast eyes and looking for hidden spots
Monday Dec 28, 2020
Monday Dec 28, 2020
How do our eyes process the continually barrage of photos so efficiently? What happens in our eyes that enables us to respond so quickly to stimulus like light or signs of danger? Why do zebra-fish swim towards the light so quickly? How does your brain process and map a room? Does the way your brain processes a space change when you're searching for something rather than exploring?
References:
- Matthias Stangl, Uros Topalovic, Cory S. Inman, Sonja Hiller, Diane Villaroman, Zahra M. Aghajan, Leonardo Christov-Moore, Nicholas R. Hasulak, Vikram R. Rao, Casey H. Halpern, Dawn Eliashiv, Itzhak Fried, Nanthia Suthana. Boundary-anchored neural mechanisms of location-encoding for self and others. Nature, 2020; DOI: 10.1038/s41586-020-03073-y
- Yvonne Kölsch, Joshua Hahn, Anna Sappington, Manuel Stemmer, António M. Fernandes, Thomas O. Helmbrecht, Shriya Lele, Salwan Butrus, Eva Laurell, Irene Arnold-Ammer, Karthik Shekhar, Joshua R. Sanes, Herwig Baier. Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Neuron, 2020; DOI: 10.1016/j.neuron.2020.12.003
Monday Aug 17, 2020
Episode 392 - How brains process and overload of information
Monday Aug 17, 2020
Monday Aug 17, 2020
Your senses bombard your brain with an overload of information, so how does it process it all? How does y our brain decide what information to focus on? The brain can focus voluntarily or involuntarily on regions of an image to best process it. How does your brain decide which parts of an image to focus on? What part of your brain helps gatekeep the waves of sensory input before it gets processed? How can your brain help regulate and manage an overload of sensory inputs.
- Antonio Fernández, Marisa Carrasco. Extinguishing Exogenous Attention via Transcranial Magnetic Stimulation. Current Biology, 2020; DOI: 10.1016/j.cub.2020.07.068
- Yinqing Li, Violeta G. Lopez-Huerta, Xian Adiconis, Kirsten Levandowski, Soonwook Choi, Sean K. Simmons, Mario A. Arias-Garcia, Baolin Guo, Annie Y. Yao, Timothy R. Blosser, Ralf D. Wimmer, Tomomi Aida, Alexander Atamian, Tina Naik, Xuyun Sun, Dasheng Bi, Diya Malhotra, Cynthia C. Hession, Reut Shema, Marcos Gomes, Taibo Li, Eunjin Hwang, Alexandra Krol, Monika Kowalczyk, João Peça, Gang Pan, Michael M. Halassa, Joshua Z. Levin, Zhanyan Fu, Guoping Feng. Distinct subnetworks of the thalamic reticular nucleus. Nature, 2020; DOI: 10.1038/s41586-020-2504-5
Monday Jul 27, 2020
Episode 389 - Chronic Pain, Ears, Long lasting Electrodes
Monday Jul 27, 2020
Monday Jul 27, 2020
Treating chronic pain through tiny electrodes in your ear. Can 3 phase like stimulating of nerves in your eye help treat chronic pain? Mapping out the inside of the ear in incredibly fine detail can help treat chronic pain. Fine tuning tiny electrodes inside the ear can help relieve chronic pain. Using a printer, tattoo paper and polymers to make long lasting electrodes. Flexible, thin and long lasting electrodes can make it easier to study the brain and the heart. Studying the brain over the long term just got easier with tattoo paper based electrodes.
- Babak Dabiri, Stefan Kampusch, Stefan H. Geyer, Van Hoang Le, Wolfgang J. Weninger, Jozsef Constantin Széles, Eugenijus Kaniusas. High-Resolution Episcopic Imaging for Visualization of Dermal Arteries and Nerves of the Auricular Cymba Conchae in Humans. Frontiers in Neuroanatomy, 2020; 14 DOI: 10.3389/fnana.2020.00022
- Laura M. Ferrari, Usein Ismailov, Jean-Michel Badier, Francesco Greco, Esma Ismailova. Conducting polymer tattoo electrodes in clinical electro- and magneto-encephalography. npj Flexible Electronics, 2020; 4 (1) DOI: 10.1038/s41528-020-0067-z
Monday Jun 01, 2020
Monday Jun 01, 2020
Finding it hard to wake up in the morning when it's cold? Don't worry you're not alone. What can we Fruit Flies teach us about wanting to stay in bed especially when it's cold outside? How do the cycles of temperature and light impact sleep? Is the right temperature key to a good night's rest? Is the optimum temperature hard coded in creatures brain or is it all relative? Getting a good night's sleep is important for keeping your brain healthy. What can zebrafish and fruit flies help us understand about getting a good night's sleep? Is there a connection between a good night's sleep and cleaning out unwanted proteins in your brain?
- Michael H. Alpert, Dominic D. Frank, Evan Kaspi, Matthieu Flourakis, Emanuela E. Zaharieva, Ravi Allada, Alessia Para, Marco Gallio. A Circuit Encoding Absolute Cold Temperature in Drosophila. Current Biology, 2020; DOI: 10.1016/j.cub.2020.04.038
- Sarah Ly, Daniel A. Lee, Ewa Strus, David A. Prober, Nirinjini Naidoo. Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK. Current Biology, 2020; DOI: 10.1016/j.cub.2020.02.030
Monday Mar 02, 2020
Episode 368 - Brain injuries, epilepsy and treatment options
Monday Mar 02, 2020
Monday Mar 02, 2020
How can we give better quality of life for those suffering from neurological conditions? Getting a concussion is bad enough, but why do people often develop epilepsy afterwards? What is the link between concussions and epilepsy? How can we effectively reduce the risk of epilepsy after a concussion? For certain epilepsy conditions in children, CBD can help reduce seizure risk, but what type is best? Is pharmaceutical or artisan CBD for children with epilepsy?
- Akshata A. Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar. Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Currents and Drives Post‐Traumatic Epileptogenesis. Annals of Neurology, 2020; DOI: 10.1002/ana.25698
- American Academy of Neurology. (2020, February 27). Artisanal CBD not as effective as pharmaceutical CBD for reducing seizures. ScienceDaily. Retrieved February 29, 2020 from www.sciencedaily.com/releases/2020/02/200227160545.htm
Monday Dec 09, 2019
Episode 356 - Responding to signs of danger
Monday Dec 09, 2019
Monday Dec 09, 2019
How do animals communicate information about danger? When a threat is detected by one animal, how do they pass it along to others? Does empathy play a role in how a create responds to a threat? Does the reaction of others around you change your response to threats? What chemical causes you to freeze in response to danger? How does serotonin cause deer in the headlights moments? What's the link between serotonin and slowing down in response to danger?
- Yingying Han, Rune Bruls, Efe Soyman, Rajat Mani Thomas, Vasiliki Pentaraki, Naomi Jelinek, Mirjam Heinemans, Iege Bassez, Sam Verschooren, Illanah Pruis, Thijs Van Lierde, Nathaly Carrillo, Valeria Gazzola, Maria Carrillo, Christian Keysers. Bidirectional cingulate-dependent danger information transfer across rats. PLOS Biology, 2019; 17 (12): e3000524 DOI: 10.1371/journal.pbio.3000524
- Clare E. Howard, Chin-Lin Chen, Tanya Tabachnik, Rick Hormigo, Pavan Ramdya, Richard S. Mann. Serotonergic Modulation of Walking in Drosophila. Current Biology, 2019; DOI: 10.1016/j.cub.2019.10.042