January 11, 2021
You've probably heard of CRISPR, but what does it mean for the world of professional sports? How could gene-doping be detected by sports administrators? Could you tell if someone had used CRISPR to 'dope' their performance? WADA considers gene editing a form of doping, but how can you detect it? What happens when you mix sweat, gym equipment and cleaning products? When you exercise you release a 3-5 times the amount of chemicals than a sedentary person. What happens to the mix of sweat, amino acids and cleaning products in the air of a gym?
- Alina Paßreiter, Andreas Thomas, Nicolas Grogna, Philippe Delahaut, Mario Thevis. First Steps toward Uncovering Gene Doping with CRISPR/Cas by Identifying SpCas9 in Plasma via HPLC–HRMS/MS. Analytical Chemistry, 2020; 92 (24): 16322 DOI: 10.1021/acs.analchem.0c04445
- Zachary Finewax, Demetrios Pagonis, Megan S. Claflin, Anne V. Handschy, Wyatt L. Brown, Olivia Jenks, Benjamin A. Nault, Douglas A. Day, Brian M. Lerner, Jose L. Jimenez, Paul J. Ziemann, Joost A. Gouw. Quantification and source characterization of volatile organic compounds from exercising and application of chlorine‐based cleaning products in a university athletic center. Indoor Air, 2020; DOI: 10.1111/ina.12781
December 28, 2020
How do our eyes process the continually barrage of photos so efficiently? What happens in our eyes that enables us to respond so quickly to stimulus like light or signs of danger? Why do zebra-fish swim towards the light so quickly? How does your brain process and map a room? Does the way your brain processes a space change when you're searching for something rather than exploring?
- Matthias Stangl, Uros Topalovic, Cory S. Inman, Sonja Hiller, Diane Villaroman, Zahra M. Aghajan, Leonardo Christov-Moore, Nicholas R. Hasulak, Vikram R. Rao, Casey H. Halpern, Dawn Eliashiv, Itzhak Fried, Nanthia Suthana. Boundary-anchored neural mechanisms of location-encoding for self and others. Nature, 2020; DOI: 10.1038/s41586-020-03073-y
- Yvonne Kölsch, Joshua Hahn, Anna Sappington, Manuel Stemmer, António M. Fernandes, Thomas O. Helmbrecht, Shriya Lele, Salwan Butrus, Eva Laurell, Irene Arnold-Ammer, Karthik Shekhar, Joshua R. Sanes, Herwig Baier. Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Neuron, 2020; DOI: 10.1016/j.neuron.2020.12.003
October 12, 2020
The Nobel Prize's legacy on gender and diversity is poor, but are they turning it around? We celebrate the winners of the Nobel Prize, but look critically at the challenges of the system. How do you recognize the collaboration of 100s or 1000s of people with a single award? Is science advanced through singular genius or the collaboration of many? How can CRISPR help us create a more sustainable planet? Growing trees that are easier to process but still able to thrive is possible with CRISPR. How can making trees with less lignin help make a greener planet?
- Advanced information. NobelPrize.org. Nobel Media AB 2020. Sat. 10 Oct 2020. <https://www.nobelprize.org/prizes/chemistry/2020/advanced-information
- Barbara De Meester, Barbara Madariaga Calderón, Lisanne de Vries, Jacob Pollier, Geert Goeminne, Jan Van Doorsselaere, Mingjie Chen, John Ralph, Ruben Vanholme, Wout Boerjan. Tailoring poplar lignin without yield penalty by combining a null and haploinsufficient CINNAMOYL-CoA REDUCTASE2 allele. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-18822-w
September 14, 2020
Is that food safe to eat? How can you tell if food has gone bad beyond just reading a date? Ever been confused by best before or use by? A new type of label could make it a mater of colors. Color based labels could help detect if your food has gone bad or is contaminated by bacteria. How can we study the microbes that live inside our intestines? The gut microbiome is incredibly fascinating but difficult to study without damaging it. A tiny pill that takes snapshots of micro organisms inside your stomach as it passes through.
- Doyoon Kim, Yunteng Cao, Dhanushkodi Mariappan, Michael S. Bono Jr., A. John Hart, Benedetto Marelli. A Microneedle Technology for Sampling and Sensing Bacteria in the Food Supply Chain. Advanced Functional Materials, 2020 DOI: 10.1002/adfm.202005370
- Lu Chen, Lina Gruzinskyte, Steffen Lynge Jørgensen, Anja Boisen, Sarvesh Kumar Srivastava. An Ingestible Self-Polymerizing System for Targeted Sampling of Gut Microbiota and Biomarkers. ACS Nano, 2020; DOI: 10.1021/acsnano.0c05426
August 17, 2020
Your senses bombard your brain with an overload of information, so how does it process it all? How does y our brain decide what information to focus on? The brain can focus voluntarily or involuntarily on regions of an image to best process it. How does your brain decide which parts of an image to focus on? What part of your brain helps gatekeep the waves of sensory input before it gets processed? How can your brain help regulate and manage an overload of sensory inputs.
- Antonio Fernández, Marisa Carrasco. Extinguishing Exogenous Attention via Transcranial Magnetic Stimulation. Current Biology, 2020; DOI: 10.1016/j.cub.2020.07.068
- Yinqing Li, Violeta G. Lopez-Huerta, Xian Adiconis, Kirsten Levandowski, Soonwook Choi, Sean K. Simmons, Mario A. Arias-Garcia, Baolin Guo, Annie Y. Yao, Timothy R. Blosser, Ralf D. Wimmer, Tomomi Aida, Alexander Atamian, Tina Naik, Xuyun Sun, Dasheng Bi, Diya Malhotra, Cynthia C. Hession, Reut Shema, Marcos Gomes, Taibo Li, Eunjin Hwang, Alexandra Krol, Monika Kowalczyk, João Peça, Gang Pan, Michael M. Halassa, Joshua Z. Levin, Zhanyan Fu, Guoping Feng. Distinct subnetworks of the thalamic reticular nucleus. Nature, 2020; DOI: 10.1038/s41586-020-2504-5
July 27, 2020
Treating chronic pain through tiny electrodes in your ear. Can 3 phase like stimulating of nerves in your eye help treat chronic pain? Mapping out the inside of the ear in incredibly fine detail can help treat chronic pain. Fine tuning tiny electrodes inside the ear can help relieve chronic pain. Using a printer, tattoo paper and polymers to make long lasting electrodes. Flexible, thin and long lasting electrodes can make it easier to study the brain and the heart. Studying the brain over the long term just got easier with tattoo paper based electrodes.
- Babak Dabiri, Stefan Kampusch, Stefan H. Geyer, Van Hoang Le, Wolfgang J. Weninger, Jozsef Constantin Széles, Eugenijus Kaniusas. High-Resolution Episcopic Imaging for Visualization of Dermal Arteries and Nerves of the Auricular Cymba Conchae in Humans. Frontiers in Neuroanatomy, 2020; 14 DOI: 10.3389/fnana.2020.00022
- Laura M. Ferrari, Usein Ismailov, Jean-Michel Badier, Francesco Greco, Esma Ismailova. Conducting polymer tattoo electrodes in clinical electro- and magneto-encephalography. npj Flexible Electronics, 2020; 4 (1) DOI: 10.1038/s41528-020-0067-z
June 8, 2020
Animals can help us monitor our environment for pollution. From silicon dog tags to tiger snakes in wetlands, animals can help us monitor pollution. How can silicon dog tags help protect humans from environmental pollutants? Cleaning up an oil spill is tricky, but with the right materials it's easy as wringing a sponge. Water hating but Oil loving magnetic sponges can help clean up after oil spills. How do Tiger snakes help us find the cleanest wetlands? Just how clean are urban wetlands?
- Catherine F. Wise, Stephanie C. Hammel, Nicholas Herkert, Jun Ma, Alison Motsinger-Reif, Heather M. Stapleton, Matthew Breen. Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research. Environmental Science & Technology, 2020; DOI: 10.1021/acs.est.9b06605
- D. C. Lettoof, P. W. Bateman, F. Aubret, M. M. Gagnon. The Broad-Scale Analysis of Metals, Trace Elements, Organochlorine Pesticides and Polycyclic Aromatic Hydrocarbons in Wetlands Along an Urban Gradient, and the Use of a High Trophic Snake as a Bioindicator. Archives of Environmental Contamination and Toxicology, 2020; 78 (4): 631 DOI: 10.1007/s00244-020-00724-z
- Vikas Nandwana, Stephanie M. Ribet, Roberto D. Reis, Yuyao Kuang, Yash More, Vinayak P. Dravid. OHM Sponge: A Versatile, Efficient, and Ecofriendly Environmental Remediation Platform. Industrial & Engineering Chemistry Research, 2020; DOI: 10.1021/acs.iecr.0c01493
June 1, 2020
Finding it hard to wake up in the morning when it's cold? Don't worry you're not alone. What can we Fruit Flies teach us about wanting to stay in bed especially when it's cold outside? How do the cycles of temperature and light impact sleep? Is the right temperature key to a good night's rest? Is the optimum temperature hard coded in creatures brain or is it all relative? Getting a good night's sleep is important for keeping your brain healthy. What can zebrafish and fruit flies help us understand about getting a good night's sleep? Is there a connection between a good night's sleep and cleaning out unwanted proteins in your brain?
- Michael H. Alpert, Dominic D. Frank, Evan Kaspi, Matthieu Flourakis, Emanuela E. Zaharieva, Ravi Allada, Alessia Para, Marco Gallio. A Circuit Encoding Absolute Cold Temperature in Drosophila. Current Biology, 2020; DOI: 10.1016/j.cub.2020.04.038
- Sarah Ly, Daniel A. Lee, Ewa Strus, David A. Prober, Nirinjini Naidoo. Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK. Current Biology, 2020; DOI: 10.1016/j.cub.2020.02.030
April 27, 2020
What can we learn from spiders webs, venom and combs? How do spiders manage to weave intricate webs without getting tangled in them? How can spider's legs help develop next generation nano materials? How can spider venom help us fight back against the opioid crisis? Spider venom is dangerous but it can also help reduce harm in pain management.
- Akello J. Agwa, Poanna Tran, Alexander Mueller, Hue N. T. Tran, Jennifer R. Deuis, Mathilde R. Israel, Kirsten L. McMahon, David J. Craik, Irina Vetter, Christina I. Schroeder. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. Journal of Biological Chemistry, 2020; 295 (15): 5067 DOI: 10.1074/jbc.RA119.012281
- Anna-Christin Joel, Marco Meyer, Johannes Heitz, Alexander Heiss, Daesung Park, Hana Adamova, Werner Baumgartner. Biomimetic Combs as Antiadhesive Tools to Manipulate Nanofibers. ACS Applied Nano Materials, 2020; 3 (4): 3395 DOI: 10.1021/acsanm.0c00130
- Po Peng, Devi Stuart‐Fox, Szu‐Wei Chen, Eunice J. Tan, Guan‐Lin Kuo, Sean J. Blamires, I‐Min Tso, Mark A. Elgar. High contrast yellow mosaic patterns are prey attractants for orb‐weaving spiders. Functional Ecology, 2020; DOI: 10.1111/1365-2435.13532
April 13, 2020
Taking the fight to bacteria with lasers, metal and insect wings. How can lasers help make a material into a bacteria destroyer? Metal in fantasy has demon slaying properties, but how can it help fight bacteria? What can we learn from insect wings to help make safer implants? What is it about silver that makes it good for killing bacteria (and werewolves). Why are metals so dangerous for bacteria? How can we treat and use metal to make medical devices safer from bacteria?
- Vidhya Selvamani, Amin Zareei, Ahmed Elkashif, Murali Kannan Maruthamuthu, Shirisha Chittiboyina, Davide Delisi, Zheng Li, Lirong Cai, Vilas G. Pol, Mohamed N. Seleem, Rahim Rahimi. Hierarchical Micro/Mesoporous Copper Structure with Enhanced Antimicrobial Property via Laser Surface Texturing. Advanced Materials Interfaces, 2020; 1901890 DOI: 10.1002/admi.201901890
- Asmaa A. Sadoon, Prabhat Khadka, Jack Freeland, Ravi Kumar Gundampati, Ryan H. Manso, Mason Ruiz, Venkata R. Krishnamurthi, Suresh Kumar Thallapuranam, Jingyi Chen, Yong Wang. Silver Ions Caused Faster Diffusive Dynamics of Histone-Like Nucleoid-Structuring Proteins in Live Bacteria. Applied and Environmental Microbiology, 2020; 86 (6) DOI: 10.1128/AEM.02479-19
- J. Jenkins, J. Mantell, C. Neal, A. Gholinia, P. Verkade, A. H. Nobbs, B. Su. Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-15471-x
March 2, 2020
How can we give better quality of life for those suffering from neurological conditions? Getting a concussion is bad enough, but why do people often develop epilepsy afterwards? What is the link between concussions and epilepsy? How can we effectively reduce the risk of epilepsy after a concussion? For certain epilepsy conditions in children, CBD can help reduce seizure risk, but what type is best? Is pharmaceutical or artisan CBD for children with epilepsy?
- Akshata A. Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar. Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Currents and Drives Post‐Traumatic Epileptogenesis. Annals of Neurology, 2020; DOI: 10.1002/ana.25698
- American Academy of Neurology. (2020, February 27). Artisanal CBD not as effective as pharmaceutical CBD for reducing seizures. ScienceDaily. Retrieved February 29, 2020 from www.sciencedaily.com/releases/2020/02/200227160545.htm
February 3, 2020
The Coronavirus family is a dangerous lot from SARS to MERS and Novel Coronavirus 2019. This week we look at the history of Coronavirus outbreaks, research into past infections and public health strategy. We do some fact checking on Coronavirus myths and fears. What lessons were learnt from the SARS outbreak of '03 that can help today in '20? How can turning off the cells recycling plant stop Coronaviruses in their tracks? What role does cell autophagy play in spreading or stopping MERS? What can we learn from the sequenced genomes of coronaviruses? How can tracking the ACE2 gene help people monitor the mutation of the coronavirus strains?
- Lewis, D. (2020). Coronavirus outbreak: what’s next? Nature. doi: 10.1038/d41586-020-00236-9
- Hollingsworth, J. (2020, January 30). The memory of SARS looms over the Wuhan virus. Here's how the outbreaks compare. Retrieved from https://edition.cnn.com/2020/01/29/china/sars-wuhan-virus-explainer-intl-hnk-scli/index.html
- Alerts - Novel coronavirus - Frequently asked questions. (n.d.). Retrieved from https://www.health.nsw.gov.au/Infectious/alerts/Pages/coronavirus-faqs.aspx#1-1
- Coronavirus latest: WHO declares global emergency. (2020, January 30). Retrieved from https://www.nature.com/articles/d41586-020-00154-w
- Yushun Wan, Jian Shang, Rachel Graham, Ralph S. Baric, Fang Li. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology, 2020; DOI: 10.1128/JVI.00127-20
- Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-13659-4
January 20, 2020
What happens next after disaster strikes and people flee for safety? How do wildlife move in when people move out of a disaster zone? How do animals moving into an evacuated area change with no humans around? What is the most effective thing to do if you live near a disaster area? How do we assess risk and life expectancy impact of living near a disaster zone? Is it more dangerous to live near a nuclear plant or in the diesel smog of the big city?
- Phillip C Lyons, Kei Okuda, Matthew T Hamilton, Thomas G Hinton, James C Beasley. Rewilding of Fukushima's human evacuation zone. Frontiers in Ecology and the Environment, 2020; DOI: 10.1002/fee.2149
- Philip Thomas, John May. Coping after a big nuclear accident. Process Safety and Environmental Protection, 2017; 112: 1 DOI: 10.1016/j.psep.2017.09.013
January 6, 2020
How do we peer into the inner workings of our cells, especially during their response to a medical emergency? What role does fibroblasts play to protect your heart after a heart attack? When is your body hardest at work repairing damage after a heart attack? What stem cells control your blood cells? How can we get a picture of the complex 3D shape of blood stem cells in your bone marrow? What role does bone marrow play in blood regulation?
- Chiara Baccin, Jude Al-Sabah, Lars Velten, Patrick M. Helbling, Florian Grünschläger, Pablo Hernández-Malmierca, César Nombela-Arrieta, Lars M. Steinmetz, Andreas Trumpp, Simon Haas. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology, 2019; DOI: 10.1038/s41556-019-0439-6
- Zohreh Varasteh, Sarajo Mohanta, Stephanie Robu, Miriam Braeuer, Yuanfang Li, Negar Omidvari, Geoffrey Topping, Ting Sun, Stephan G. Nekolla, Antonia Richter, Christian Weber, Andreas Habenicht, Uwe A. Haberkorn, Wolfgang A. Weber. Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using a 68Ga-Labeled Fibroblast Activation Protein Inhibitor, FAPI-04. Journal of Nuclear Medicine, 2019; 60 (12): 1743 DOI: 10.2967/jnumed.119.226993
December 9, 2019
How do animals communicate information about danger? When a threat is detected by one animal, how do they pass it along to others? Does empathy play a role in how a create responds to a threat? Does the reaction of others around you change your response to threats? What chemical causes you to freeze in response to danger? How does serotonin cause deer in the headlights moments? What's the link between serotonin and slowing down in response to danger?
- Yingying Han, Rune Bruls, Efe Soyman, Rajat Mani Thomas, Vasiliki Pentaraki, Naomi Jelinek, Mirjam Heinemans, Iege Bassez, Sam Verschooren, Illanah Pruis, Thijs Van Lierde, Nathaly Carrillo, Valeria Gazzola, Maria Carrillo, Christian Keysers. Bidirectional cingulate-dependent danger information transfer across rats. PLOS Biology, 2019; 17 (12): e3000524 DOI: 10.1371/journal.pbio.3000524
- Clare E. Howard, Chin-Lin Chen, Tanya Tabachnik, Rick Hormigo, Pavan Ramdya, Richard S. Mann. Serotonergic Modulation of Walking in Drosophila. Current Biology, 2019; DOI: 10.1016/j.cub.2019.10.042
November 11, 2019
This week we look at the way our brains process sound, music, pitch and rhythm. How does our brain figure out where a sound is coming from? Do our eyes and ears process distance and location in a similar way? How does our brain discern differences in stimuli? What can we learn about pitch and rhythm from studying a remote Bolivian tribe? Is there a biological limit to our perception of sounds? Is our ability to perceive rhythm, chords and pitch cultural or biological?
- Antje Ihlefeld, Nima Alamatsaz, Robert M Shapley. Population rate-coding predicts correctly that human sound localization depends on sound intensity. eLife, 2019; 8 DOI: 10.7554/eLife.47027
- Nori Jacoby, Eduardo A. Undurraga, Malinda J. McPherson, Joaquín Valdés, Tomás Ossandón, Josh H. McDermott. Universal and Non-universal Features of Musical Pitch Perception Revealed by Singing. Current Biology, 2019; DOI: 10.1016/j.cub.2019.08.020
October 21, 2019
Humans have been using micro-organisms like fungus and bacteria to help improve our food for millennia. Can we tame new wild species of fungus to help create new types of our favourite foods like cheese? Penicillin is mostly known for antibiotics but it also helps give Camembert its particular taste. What causes cheese to rapidly tame wild strains of fungus? We are not the only ones who use microbes to help our food. Ants help stop disease from destroying plants by spreading their own antibiotics. Ant base antibiotics help stop plant pathogens. Sometimes bacteria don't fight against each other but rather team up and work together. Survival of kindest rules for bacteria, which helps different strains work together to survive.
- Bodinaku, I., Shaffer, J., Connors, A. B., Steenwyk, J. L., Biango-Daniels, M. N., Kastman, E. K., … Wolfe, B. E. (2019). Rapid Phenotypic and Metabolomic Domestication of Wild Penicillium Molds on Cheese. MBio, 10(5). doi: 10.1128/mbio.02445-19
- Joachim Offenberg, Christian Damgaard. Ants suppressing plant pathogens: a review. Oikos, 2019; DOI: 10.1111/oik.06744
- Wenzheng Liu, Samuel Jacquiod, Asker Brejnrod, Jakob Russel, Mette Burmølle, Søren J. Sørensen. Deciphering links between bacterial interactions and spatial organization in multispecies biofilms. The ISME Journal, 2019; DOI: 10.1038/s41396-019-0494-9
September 30, 2019
Washing machines can save a lot of time and help clean up mess, but they can also harm our health and environment. Which washing process is better for the environment - full an fast or empty and delicate? How do washing machines help fill our oceans with microplastics? What can be done to help stop washing machines contributing to the microplastics in our waterways? Which washing setting is best for your health? Cold and clean or warm and soapy? How did a normal washing machine cause havoc in a hospital? How can you multi-drug resistant pathogens spread through a washing machine?
- American Society for Microbiology. (2019, September 27). Your energy-efficient washing machine could be harboring pathogens: Lower temperatures used in 'energy saver' washing machines may not be killing all pathogens. ScienceDaily. Retrieved September 29, 2019 from www.sciencedaily.com/releases/2019/09/190927135202.htm
- Max R. Kelly, Neil J. Lant, Martyn Kurr, J. Grant Burgess. Importance of Water-Volume on the Release of Microplastic Fibers from Laundry. Environmental Science & Technology, 2019; DOI: 10.1021/acs.est.9b03022
September 23, 2019
Is it possible to stop Alzheimer's in it's tracks? How does the formation of plaques on your brain cells lead to Alzheimer's. Does the your brain immune cells fighting back against plaques lead to Alzheimers? Amino acids in the brain tying themselves into knots, can lead to super strong sealed zippers forming which dry out proteins, damage neurons and eventually can lead to diseases like Alzheimer's. An enzyme missing a repair or two over 60 years can lead to build up of kinked amino acids chains which can lead to neuron-degenerative diseases. What causes a cell to eat itself? Well its actually a pretty healthy thing to do. If a brain cell doesn't eat itself at the right time, well it can lead to a whole bunch of diseases.
- Rebeccah A. Warmack, David R. Boyer, Chih-Te Zee, Logan S. Richards, Michael R. Sawaya, Duilio Cascio, Tamir Gonen, David S. Eisenberg, Steven G. Clarke. Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11183-z
- Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11674-z
- Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11671-2
August 26, 2019
Your brain uses proteins synthesis and redundancy to help form and keep memories. Intricate biochemistry helps your neurons connect to each other to form new memories. Forming new memories is a sticky situation. Keeping them stuck together over time in a long lasting memory relies on protein synthesis. Its important not just to have strong connections between neurons to form memories, you also need spares. By having redundancy and backups it means that you can still remember a key memory if one of those connections fails.
- Lenzie Ford et al. CPEB3 inhibits translation of mRNA targets by localizing them to P bodies. PNAS, 2019 DOI: 10.1073/pnas.1815275116
- Walter G. Gonzalez, Hanwen Zhang, Anna Harutyunyan, Carlos Lois. Persistence of neuronal representations through time and damage in the hippocampus. Science, 2019: Vol. 365, Issue 6455, pp. 821-825 DOI: 10.1126/science.aav9199