August 30, 2021
Your brain and gut are connected in surprising ways. Inside your GI tract is a surprisingly complex nervous system. Your GI tract has it's own nervous system which is more like the spine than other organs. How does your GI tract differ from other soft hollow organs? The connection between gut microbiomes and brains is clear, but not well understood. Certain microbes can cause neurodegeneration in brains just as bad as a poor diet and no oxygen. How can we stop brains copy and pasting toxic byproducts across our brains? Proteins keep our brains in check and prevent build up of toxic byproducts, but this can be used to put the brakes on neurodegeneration.
- Nick J. Spencer, Lee Travis, Lukasz Wiklendt, Marcello Costa, Timothy J. Hibberd, Simon J. Brookes, Phil Dinning, Hongzhen Hu, David A. Wattchow, Julian Sorensen. Long range synchronization within the enteric nervous system underlies propulsion along the large intestine in mice. Communications Biology, 2021; 4 (1) DOI: 10.1038/s42003-021-02485-4
- Christine A. Olson, Alonso J. Iñiguez, Grace E. Yang, Ping Fang, Geoffrey N. Pronovost, Kelly G. Jameson, Tomiko K. Rendon, Jorge Paramo, Jacob T. Barlow, Rustem F. Ismagilov, Elaine Y. Hsiao. Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia. Cell Host & Microbe, 2021; DOI: 10.1016/j.chom.2021.07.004
- Chingakham Ranjit Singh, M. Rebecca Glineburg, Chelsea Moore, Naoki Tani, Rahul Jaiswal, Ye Zou, Eric Aube, Sarah Gillaspie, Mackenzie Thornton, Ariana Cecil, Madelyn Hilgers, Azuma Takasu, Izumi Asano, Masayo Asano, Carlos R. Escalante, Akira Nakamura, Peter K. Todd, Katsura Asano. Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism. Cell Reports, 2021; 36 (2): 109376 DOI: 10.1016/j.celrep.2021.109376
July 26, 2021
Using technology and tools to make the human body safer. How can we use exoskeletons to keep people safe? Does using a tool like an exoskeleton automatically make a task easier? How can technology that augments bodys hinder when trying to help? How can we keep our head safer during a collision. Countless people rely on bicycles for safe and green transport, but how do we make it safer? Bicycle helmets are a simple tool for helping save lives, but can they be made even safer with new materials?
- Yibo Zhu, Eric B. Weston, Ranjana K. Mehta, William S. Marras. Neural and biomechanical tradeoffs associated with human-exoskeleton interactions. Applied Ergonomics, 2021; 96: 103494 DOI: 10.1016/j.apergo.2021.103494
- Karl A Zimmerman, Etienne Laverse, Ravjeet Samra, Maria Yanez Lopez, Amy E Jolly, Niall J Bourke, Neil S N Graham, Maneesh C Patel, John Hardy, Simon Kemp, Huw R Morris, David J Sharp. White matter abnormalities in active elite adult rugby players. Brain Communications, 2021; 3 (3) DOI: 10.1093/braincomms/fcab133
July 19, 2021
Turning off plants with a switch of a light. How can optogenetics be used to turn off photosynthesis. Stomata cells help a plant from feasting too much in times of famine. Stomata cells regulate how much photosynthesis plants undertake, but can they be regulated with light? How can Yeast be used to help plants fight back against fungus. Fungal infections can devastate crops and plants, but can we avoid dangerous fungicides? How can we protect plants from, fungi without damaging the environment? Can yeast grown proteins help stop fungal infections without killing all fungi?
- Tiffany Chiu, Anita Behari, Justin W. Chartron, Alexander Putman, Yanran Li. Exploring the potential of engineering polygalacturonase‐inhibiting protein as an ecological, friendly, and nontoxic pest control agent. Biotechnology and Bioengineering, 2021; DOI: 10.1002/bit.27845
- Shouguang Huang, Meiqi Ding, M. Rob G. Roelfsema, Ingo Dreyer, Sönke Scherzer, Khaled A. S. Al-Rasheid, Shiqiang Gao, Georg Nagel, Rainer Hedrich, Kai R. Konrad. Optogenetic control of the guard cell membrane potential and stomatal movement by the light-gated anion channel GtACR1. Science Advances, 2021; 7 (28): eabg4619 DOI: 10.1126/sciadv.abg4619
June 7, 2021
Insects and plants are locked into an arms race until something breaks the stalemate. How can a tag team attack of bacteria and insect larvae help crush through a leaf's defenses? WOrkign together as a team, larvae and bacteria can make a tasty meal out of a leaf. Plants can fight back against insets, so insects need to call out for help. A parasitic infection is bad for the host, but some ants gain an odd boost. How are tapeworms boosting the life expectancy of ants? When an ant gets infected with parasites, it's colony mates care for it boosting it's lifespan.
- Yukiyo Yamasaki, Hiroka Sumioka, Mayu Takiguchi, Takuya Uemura, Yuka Kihara, Tomonori Shinya, Ivan Galis, Gen‐ichiro Arimura. Phytohormone‐dependent plant defense signaling orchestrated by oral bacteria of the herbivore Spodoptera litura. New Phytologist, 2021; DOI: 10.1111/nph.17444
- Sara Beros, Anna Lenhart, Inon Scharf, Matteo Antoine Negroni, Florian Menzel, Susanne Foitzik. Extreme lifespan extension in tapeworm-infected ant workers. Royal Society Open Science, 2021; 8 (5): 202118 DOI: 10.1098/rsos.202118
May 31, 2021
How does your brain decide what's important to remember? You're constantly bombarded with info so how does your brain filter it all? Do memories change over time? Do certain details stand out more in our memories over time? What details can get lost in our memories over time? How does you brain know if it's worth 'saving' that picture you've seen. How does your brain filter out and only store the important stuff.
- Julia Lifanov, Juan Linde-Domingo, Maria Wimber. Feature-specific reaction times reveal a semanticisation of memories over time and with repeated remembering. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-23288-5
- Vahid Mehrpour, Travis Meyer, Eero P. Simoncelli, Nicole C. Rust. Pinpointing the neural signatures of single-exposure visual recognition memory. Proceedings of the National Academy of Sciences, 2021; 118 (18): e2021660118 DOI: 10.1073/pnas.2021660118
April 19, 2021
How does RNA work to protect your brain and keep it safe after a traumatic event? Micro RNA can play an important role in healthy brain development. Without key micro RNA, the development of the brain can run out of control. Without key microRNA, your can develop neurodevelopmental disorders. Without oxygen your neurons starve, so how can you protect them? How can you use mRNA to make neurons more resilient and recover after a lack of oxygen? Getting proteins across the blood brain barrier is tricky, so can they be snuck in via mRNA? Using mRNA, you can produce proteins to add brain recovery right where they're needed most.
- Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Hume Stroud, Jeremy M. Simon, Travis S. Ptacek, Matthew V. Beck, Cornelius Flowers, Jiami Guo, Charlotte Plestant, Jie Liang, C. Lisa Kurtz, Matt Kanke, Scott M. Hammond, You-Wen He, E.S. Anton, Praveen Sethupathy, Sheryl S. Moy, Michael E. Greenberg, Mohanish Deshmukh. MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation. Cell Reports, 2021; 35 (1): 108946 DOI: 10.1016/j.celrep.2021.108946
- Merlin Crossley,Dean of Science and Professor of Molecular Biology. (2021, April 09). Explainer: What is rna? Retrieved April 13, 2021, from https://theconversation.com/explainer-what-is-rna-15169
- Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle. Biomaterials, 2021; 270: 120681 DOI: 10.1016/j.biomaterials.2021.120681
March 22, 2021
Space is hard, things are different there which means something simple as salmonella becomes much more challenging. The rules of bacterial infection and response change once you're in space. How does your body respond to bacterial infection in microgravity environments? Getting sick in space may be worse than on earth. The human microbiome is incredible diverse and not well understood. Your gut contains 100,000s of bacteria groups, virus and other things. A large global study of gut microbiome has revealed thousands of new virus and bacteria types.
- Jennifer Barrila, Shameema F. Sarker, Nicole Hansmeier, Shanshan Yang, Kristina Buss, Natalia Briones, Jin Park, Richard R. Davis, Rebecca J. Forsyth, C. Mark Ott, Kevin Sato, Cristine Kosnik, Anthony Yang, Cheryl Shimoda, Nicole Rayl, Diana Ly, Aaron Landenberger, Stephanie D. Wilson, Naoko Yamazaki, Jason Steel, Camila Montano, Rolf U. Halden, Tom Cannon, Sarah L. Castro-Wallace, Cheryl A. Nickerson. Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium. npj Microgravity, 2021; 7 (1) DOI: 10.1038/s41526-021-00136-w
- Luis F. Camarillo-Guerrero, Alexandre Almeida, Guillermo Rangel-Pineros, Robert D. Finn, Trevor D. Lawley. Massive expansion of human gut bacteriophage diversity. Cell, 2021; 184 (4): 1098 DOI: 10.1016/j.cell.2021.01.029
February 1, 2021
Sourdough baking has rising to become a global hobby, but how diverse are they? Each sourdough starter is a tiny ecosystem, and a global study shows how diverse they are. Scientists analysed 500 sourdough from across the world to find out what makes the best loaf. Baking is about carefully cultivating a microbiome. What can be done to make wheat and peanuts less dangerous for people with allergies? Can you make wheat and peanuts that are better for allergies?
- Elizabeth A Landis, Angela M Oliverio, Erin A McKenney, Lauren M Nichols, Nicole Kfoury, Megan Biango-Daniels, Leonora K Shell, Anne A Madden, Lori Shapiro, Shravya Sakunala, Kinsey Drake, Albert Robbat, Matthew Booker, Robert R Dunn, Noah Fierer, Benjamin E Wolfe. The diversity and function of sourdough starter microbiomes. eLife, 2021; 10 DOI: 10.7554/eLife.61644
- American Society of Agronomy. (2021, January 27). Making wheat and peanuts less allergenic. ScienceDaily. Retrieved January 30, 2021 from www.sciencedaily.com/releases/2021/01/210127085239.htm
January 11, 2021
You've probably heard of CRISPR, but what does it mean for the world of professional sports? How could gene-doping be detected by sports administrators? Could you tell if someone had used CRISPR to 'dope' their performance? WADA considers gene editing a form of doping, but how can you detect it? What happens when you mix sweat, gym equipment and cleaning products? When you exercise you release a 3-5 times the amount of chemicals than a sedentary person. What happens to the mix of sweat, amino acids and cleaning products in the air of a gym?
- Alina Paßreiter, Andreas Thomas, Nicolas Grogna, Philippe Delahaut, Mario Thevis. First Steps toward Uncovering Gene Doping with CRISPR/Cas by Identifying SpCas9 in Plasma via HPLC–HRMS/MS. Analytical Chemistry, 2020; 92 (24): 16322 DOI: 10.1021/acs.analchem.0c04445
- Zachary Finewax, Demetrios Pagonis, Megan S. Claflin, Anne V. Handschy, Wyatt L. Brown, Olivia Jenks, Benjamin A. Nault, Douglas A. Day, Brian M. Lerner, Jose L. Jimenez, Paul J. Ziemann, Joost A. Gouw. Quantification and source characterization of volatile organic compounds from exercising and application of chlorine‐based cleaning products in a university athletic center. Indoor Air, 2020; DOI: 10.1111/ina.12781
December 28, 2020
How do our eyes process the continually barrage of photos so efficiently? What happens in our eyes that enables us to respond so quickly to stimulus like light or signs of danger? Why do zebra-fish swim towards the light so quickly? How does your brain process and map a room? Does the way your brain processes a space change when you're searching for something rather than exploring?
- Matthias Stangl, Uros Topalovic, Cory S. Inman, Sonja Hiller, Diane Villaroman, Zahra M. Aghajan, Leonardo Christov-Moore, Nicholas R. Hasulak, Vikram R. Rao, Casey H. Halpern, Dawn Eliashiv, Itzhak Fried, Nanthia Suthana. Boundary-anchored neural mechanisms of location-encoding for self and others. Nature, 2020; DOI: 10.1038/s41586-020-03073-y
- Yvonne Kölsch, Joshua Hahn, Anna Sappington, Manuel Stemmer, António M. Fernandes, Thomas O. Helmbrecht, Shriya Lele, Salwan Butrus, Eva Laurell, Irene Arnold-Ammer, Karthik Shekhar, Joshua R. Sanes, Herwig Baier. Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Neuron, 2020; DOI: 10.1016/j.neuron.2020.12.003
October 12, 2020
The Nobel Prize's legacy on gender and diversity is poor, but are they turning it around? We celebrate the winners of the Nobel Prize, but look critically at the challenges of the system. How do you recognize the collaboration of 100s or 1000s of people with a single award? Is science advanced through singular genius or the collaboration of many? How can CRISPR help us create a more sustainable planet? Growing trees that are easier to process but still able to thrive is possible with CRISPR. How can making trees with less lignin help make a greener planet?
- Advanced information. NobelPrize.org. Nobel Media AB 2020. Sat. 10 Oct 2020. <https://www.nobelprize.org/prizes/chemistry/2020/advanced-information
- Barbara De Meester, Barbara Madariaga Calderón, Lisanne de Vries, Jacob Pollier, Geert Goeminne, Jan Van Doorsselaere, Mingjie Chen, John Ralph, Ruben Vanholme, Wout Boerjan. Tailoring poplar lignin without yield penalty by combining a null and haploinsufficient CINNAMOYL-CoA REDUCTASE2 allele. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-18822-w
September 14, 2020
Is that food safe to eat? How can you tell if food has gone bad beyond just reading a date? Ever been confused by best before or use by? A new type of label could make it a mater of colors. Color based labels could help detect if your food has gone bad or is contaminated by bacteria. How can we study the microbes that live inside our intestines? The gut microbiome is incredibly fascinating but difficult to study without damaging it. A tiny pill that takes snapshots of micro organisms inside your stomach as it passes through.
- Doyoon Kim, Yunteng Cao, Dhanushkodi Mariappan, Michael S. Bono Jr., A. John Hart, Benedetto Marelli. A Microneedle Technology for Sampling and Sensing Bacteria in the Food Supply Chain. Advanced Functional Materials, 2020 DOI: 10.1002/adfm.202005370
- Lu Chen, Lina Gruzinskyte, Steffen Lynge Jørgensen, Anja Boisen, Sarvesh Kumar Srivastava. An Ingestible Self-Polymerizing System for Targeted Sampling of Gut Microbiota and Biomarkers. ACS Nano, 2020; DOI: 10.1021/acsnano.0c05426
August 17, 2020
Your senses bombard your brain with an overload of information, so how does it process it all? How does y our brain decide what information to focus on? The brain can focus voluntarily or involuntarily on regions of an image to best process it. How does your brain decide which parts of an image to focus on? What part of your brain helps gatekeep the waves of sensory input before it gets processed? How can your brain help regulate and manage an overload of sensory inputs.
- Antonio Fernández, Marisa Carrasco. Extinguishing Exogenous Attention via Transcranial Magnetic Stimulation. Current Biology, 2020; DOI: 10.1016/j.cub.2020.07.068
- Yinqing Li, Violeta G. Lopez-Huerta, Xian Adiconis, Kirsten Levandowski, Soonwook Choi, Sean K. Simmons, Mario A. Arias-Garcia, Baolin Guo, Annie Y. Yao, Timothy R. Blosser, Ralf D. Wimmer, Tomomi Aida, Alexander Atamian, Tina Naik, Xuyun Sun, Dasheng Bi, Diya Malhotra, Cynthia C. Hession, Reut Shema, Marcos Gomes, Taibo Li, Eunjin Hwang, Alexandra Krol, Monika Kowalczyk, João Peça, Gang Pan, Michael M. Halassa, Joshua Z. Levin, Zhanyan Fu, Guoping Feng. Distinct subnetworks of the thalamic reticular nucleus. Nature, 2020; DOI: 10.1038/s41586-020-2504-5
July 27, 2020
Treating chronic pain through tiny electrodes in your ear. Can 3 phase like stimulating of nerves in your eye help treat chronic pain? Mapping out the inside of the ear in incredibly fine detail can help treat chronic pain. Fine tuning tiny electrodes inside the ear can help relieve chronic pain. Using a printer, tattoo paper and polymers to make long lasting electrodes. Flexible, thin and long lasting electrodes can make it easier to study the brain and the heart. Studying the brain over the long term just got easier with tattoo paper based electrodes.
- Babak Dabiri, Stefan Kampusch, Stefan H. Geyer, Van Hoang Le, Wolfgang J. Weninger, Jozsef Constantin Széles, Eugenijus Kaniusas. High-Resolution Episcopic Imaging for Visualization of Dermal Arteries and Nerves of the Auricular Cymba Conchae in Humans. Frontiers in Neuroanatomy, 2020; 14 DOI: 10.3389/fnana.2020.00022
- Laura M. Ferrari, Usein Ismailov, Jean-Michel Badier, Francesco Greco, Esma Ismailova. Conducting polymer tattoo electrodes in clinical electro- and magneto-encephalography. npj Flexible Electronics, 2020; 4 (1) DOI: 10.1038/s41528-020-0067-z
June 8, 2020
Animals can help us monitor our environment for pollution. From silicon dog tags to tiger snakes in wetlands, animals can help us monitor pollution. How can silicon dog tags help protect humans from environmental pollutants? Cleaning up an oil spill is tricky, but with the right materials it's easy as wringing a sponge. Water hating but Oil loving magnetic sponges can help clean up after oil spills. How do Tiger snakes help us find the cleanest wetlands? Just how clean are urban wetlands?
- Catherine F. Wise, Stephanie C. Hammel, Nicholas Herkert, Jun Ma, Alison Motsinger-Reif, Heather M. Stapleton, Matthew Breen. Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research. Environmental Science & Technology, 2020; DOI: 10.1021/acs.est.9b06605
- D. C. Lettoof, P. W. Bateman, F. Aubret, M. M. Gagnon. The Broad-Scale Analysis of Metals, Trace Elements, Organochlorine Pesticides and Polycyclic Aromatic Hydrocarbons in Wetlands Along an Urban Gradient, and the Use of a High Trophic Snake as a Bioindicator. Archives of Environmental Contamination and Toxicology, 2020; 78 (4): 631 DOI: 10.1007/s00244-020-00724-z
- Vikas Nandwana, Stephanie M. Ribet, Roberto D. Reis, Yuyao Kuang, Yash More, Vinayak P. Dravid. OHM Sponge: A Versatile, Efficient, and Ecofriendly Environmental Remediation Platform. Industrial & Engineering Chemistry Research, 2020; DOI: 10.1021/acs.iecr.0c01493
June 1, 2020
Finding it hard to wake up in the morning when it's cold? Don't worry you're not alone. What can we Fruit Flies teach us about wanting to stay in bed especially when it's cold outside? How do the cycles of temperature and light impact sleep? Is the right temperature key to a good night's rest? Is the optimum temperature hard coded in creatures brain or is it all relative? Getting a good night's sleep is important for keeping your brain healthy. What can zebrafish and fruit flies help us understand about getting a good night's sleep? Is there a connection between a good night's sleep and cleaning out unwanted proteins in your brain?
- Michael H. Alpert, Dominic D. Frank, Evan Kaspi, Matthieu Flourakis, Emanuela E. Zaharieva, Ravi Allada, Alessia Para, Marco Gallio. A Circuit Encoding Absolute Cold Temperature in Drosophila. Current Biology, 2020; DOI: 10.1016/j.cub.2020.04.038
- Sarah Ly, Daniel A. Lee, Ewa Strus, David A. Prober, Nirinjini Naidoo. Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK. Current Biology, 2020; DOI: 10.1016/j.cub.2020.02.030
April 27, 2020
What can we learn from spiders webs, venom and combs? How do spiders manage to weave intricate webs without getting tangled in them? How can spider's legs help develop next generation nano materials? How can spider venom help us fight back against the opioid crisis? Spider venom is dangerous but it can also help reduce harm in pain management.
- Akello J. Agwa, Poanna Tran, Alexander Mueller, Hue N. T. Tran, Jennifer R. Deuis, Mathilde R. Israel, Kirsten L. McMahon, David J. Craik, Irina Vetter, Christina I. Schroeder. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. Journal of Biological Chemistry, 2020; 295 (15): 5067 DOI: 10.1074/jbc.RA119.012281
- Anna-Christin Joel, Marco Meyer, Johannes Heitz, Alexander Heiss, Daesung Park, Hana Adamova, Werner Baumgartner. Biomimetic Combs as Antiadhesive Tools to Manipulate Nanofibers. ACS Applied Nano Materials, 2020; 3 (4): 3395 DOI: 10.1021/acsanm.0c00130
- Po Peng, Devi Stuart‐Fox, Szu‐Wei Chen, Eunice J. Tan, Guan‐Lin Kuo, Sean J. Blamires, I‐Min Tso, Mark A. Elgar. High contrast yellow mosaic patterns are prey attractants for orb‐weaving spiders. Functional Ecology, 2020; DOI: 10.1111/1365-2435.13532
April 13, 2020
Taking the fight to bacteria with lasers, metal and insect wings. How can lasers help make a material into a bacteria destroyer? Metal in fantasy has demon slaying properties, but how can it help fight bacteria? What can we learn from insect wings to help make safer implants? What is it about silver that makes it good for killing bacteria (and werewolves). Why are metals so dangerous for bacteria? How can we treat and use metal to make medical devices safer from bacteria?
- Vidhya Selvamani, Amin Zareei, Ahmed Elkashif, Murali Kannan Maruthamuthu, Shirisha Chittiboyina, Davide Delisi, Zheng Li, Lirong Cai, Vilas G. Pol, Mohamed N. Seleem, Rahim Rahimi. Hierarchical Micro/Mesoporous Copper Structure with Enhanced Antimicrobial Property via Laser Surface Texturing. Advanced Materials Interfaces, 2020; 1901890 DOI: 10.1002/admi.201901890
- Asmaa A. Sadoon, Prabhat Khadka, Jack Freeland, Ravi Kumar Gundampati, Ryan H. Manso, Mason Ruiz, Venkata R. Krishnamurthi, Suresh Kumar Thallapuranam, Jingyi Chen, Yong Wang. Silver Ions Caused Faster Diffusive Dynamics of Histone-Like Nucleoid-Structuring Proteins in Live Bacteria. Applied and Environmental Microbiology, 2020; 86 (6) DOI: 10.1128/AEM.02479-19
- J. Jenkins, J. Mantell, C. Neal, A. Gholinia, P. Verkade, A. H. Nobbs, B. Su. Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-15471-x
March 2, 2020
How can we give better quality of life for those suffering from neurological conditions? Getting a concussion is bad enough, but why do people often develop epilepsy afterwards? What is the link between concussions and epilepsy? How can we effectively reduce the risk of epilepsy after a concussion? For certain epilepsy conditions in children, CBD can help reduce seizure risk, but what type is best? Is pharmaceutical or artisan CBD for children with epilepsy?
- Akshata A. Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar. Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Currents and Drives Post‐Traumatic Epileptogenesis. Annals of Neurology, 2020; DOI: 10.1002/ana.25698
- American Academy of Neurology. (2020, February 27). Artisanal CBD not as effective as pharmaceutical CBD for reducing seizures. ScienceDaily. Retrieved February 29, 2020 from www.sciencedaily.com/releases/2020/02/200227160545.htm
February 3, 2020
The Coronavirus family is a dangerous lot from SARS to MERS and Novel Coronavirus 2019. This week we look at the history of Coronavirus outbreaks, research into past infections and public health strategy. We do some fact checking on Coronavirus myths and fears. What lessons were learnt from the SARS outbreak of '03 that can help today in '20? How can turning off the cells recycling plant stop Coronaviruses in their tracks? What role does cell autophagy play in spreading or stopping MERS? What can we learn from the sequenced genomes of coronaviruses? How can tracking the ACE2 gene help people monitor the mutation of the coronavirus strains?
- Lewis, D. (2020). Coronavirus outbreak: what’s next? Nature. doi: 10.1038/d41586-020-00236-9
- Hollingsworth, J. (2020, January 30). The memory of SARS looms over the Wuhan virus. Here's how the outbreaks compare. Retrieved from https://edition.cnn.com/2020/01/29/china/sars-wuhan-virus-explainer-intl-hnk-scli/index.html
- Alerts - Novel coronavirus - Frequently asked questions. (n.d.). Retrieved from https://www.health.nsw.gov.au/Infectious/alerts/Pages/coronavirus-faqs.aspx#1-1
- Coronavirus latest: WHO declares global emergency. (2020, January 30). Retrieved from https://www.nature.com/articles/d41586-020-00154-w
- Yushun Wan, Jian Shang, Rachel Graham, Ralph S. Baric, Fang Li. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology, 2020; DOI: 10.1128/JVI.00127-20
- Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-13659-4