Lagrange Point

Seeing how something happens makes it much easier to understand. Biological process can be very hard to capture with images or video. Understanding how a protein requires thinking in 3D but to take images of them we often have to 'snap freeze' them in place. How can lasers, ions and quantum mechanics be used to help capture a protein in motion. PCR based diagnostics tests are accurate but require a lot of setup and expertise. Can you make a PCR test more like a point of care test using bio-luminescence.

1. Shiny Maity, Brad D. Price, C. Blake Wilson, Arnab Mukherjee, Matthieu Starck, David Parker, Maxwell Z. Wilson, Janet E. Lovett, Songi Han, Mark S. Sherwin. Triggered Functional Dynamics of AsLOV2 by Time‐Resolved Electron Paramagnetic Resonance at High Magnetic Fields. Angewandte Chemie International Edition, 2023; 62 (13) DOI: 10.1002/anie.202212832
2. Harmen J. van der Veer, Eva A. van Aalen, Claire M. S. Michielsen, Eva T. L. Hanckmann, Jeroen Deckers, Marcel M. G. J. van Borren, Jacky Flipse, Anne J. M. Loonen, Joost P. H. Schoeber, Maarten Merkx. Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation. ACS Central Science, 2023; DOI: 10.1021/acscentsci.2c01467

Life in a radiation exclusion zone is challenging but not impossible. We find out about tales of survival, endurance and adaption in radiation zones and in March Mammal Madness. How does life adapt to high exposure of toxic chemicals, radiation and heavy metals? Studying the DNA of differing animal populations in Chernobyl helps researchers understand how life responds to environmental disasters.  What's more stressful for wild boar - humans or a radiation disaster zone? Around Fukashima wild boar and snakes are thriving in what is classified as a radiation disaster zone. We also preview March Mammal Madness and find out about the different divisions in this year's edition.

1. March Mammal Madness resources compiled by Arizona State University https://libguides.asu.edu/marchmammalmadness
2. Megan N. Dillon, Rachael Thomas, Timothy A. Mousseau, Jennifer A. Betz, Norman J. Kleiman, Martha O. Burford Reiskind, Matthew Breen. Population dynamics and genome-wide selection scan for dogs in Chernobyl. Canine Medicine and Genetics, 2023; 10 (1) DOI: 10.1186/s40575-023-00124-1
3. Kelly Cunningham, Thomas G. Hinton, Jared J. Luxton, Aryn Bordman, Kei Okuda, Lynn E. Taylor, Josh Hayes, Hannah C. Gerke, Sarah M. Chinn, Donovan Anderson, Mark L. Laudenslager, Tsugiko Takase, Yui Nemoto, Hiroko Ishiniwa, James C. Beasley, Susan M. Bailey. Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident. Environment International, 2021; 155: 106675 DOI: 10.1016/j.envint.2021.106675

How did birds end up with their trademark beaks? You can broadly group birds into two categories, ancient and modern jaws or beaks. We thought mobile beaks were a modern invention but new fossils overturn this idea. Just when did birds first develop their modern mobile beaks? Wild jungle fowl were domesticated to become the chickens we love today. But wild chickens are not isolated completely from modern ones. Gene transfers between wild and domesticated chickens are eroding the genetic diversity of the species.

1. Benjamin A. Tonelli, Casey Youngflesh, Morgan W. Tingley. Geomagnetic disturbance associated with increased vagrancy in migratory landbirds. Scientific Reports, 2023; 13 (1) DOI: 10.1038/s41598-022-26586-0
2. Meng Yue Wu, Giovanni Forcina, Gabriel Weijie Low, Keren R. Sadanandan, Chyi Yin Gwee, Hein van Grouw, Shaoyuan Wu, Scott V. Edwards, Maude W. Baldwin, Frank E. Rheindt. Historic samples reveal loss of wild genotype through domestic chicken introgression during the Anthropocene. PLOS Genetics, 2023; 19 (1): e1010551 DOI: 10.1371/journal.pgen.1010551

In the northern reaches of Japan in a idyllic lake, cute green balls of algae are battling for survival. It sounds like an anime, but cute green algae balls, Marimo, are battling stellar forces. Too much sunlight can endanger the cute green algae balls, the Marimo. Having too much sunlight can be just as bad for algae as too little. How can brown algae help fight back against climate change? Algae have changed the climate once before, so can they do it again? If you were to quantify the carbon sequestration of algae, would it really make an impact globally?

1. Akina Obara, Mari Ogawa, Yoichi Oyama, Yoshihiro Suzuki, Masaru Kono. Effects of High Irradiance and Low Water Temperature on Photoinhibition and Repair of Photosystems in Marimo (Aegagropila linnaei) in Lake Akan, Japan. International Journal of Molecular Sciences, 2022; 24 (1): 60 DOI: 10.3390/ijms24010060
2. Hagen Buck-Wiese, Mona A. Andskog, Nguyen P. Nguyen, Margot Bligh, Eero Asmala, Silvia Vidal-Melgosa, Manuel Liebeke, Camilla Gustafsson, Jan-Hendrik Hehemann. Fucoid brown algae inject fucoidan carbon into the ocean. Proceedings of the National Academy of Sciences, 2022; 120 (1) DOI: 10.1073/pnas.2210561119

Understanding how our body senses and interacts with the world. Scientists are only now beginning to understand how our body senses the world, hence the '21 Nobel Prizes. This Nobel prize wining research helped others find a connection between the gut and our sense of touch. Internal organ pain can be crippling and require side effect laden treatments. How do organs like the gut detect and transmit pain signals? The same mechanism to detect soft touch is used by your organs to send pain signals. How does our body precisely control temperature? What region of the brain measures and control what temperature to set itself to?

1. Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, Hongzhen Hu. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron, 2022; DOI: 10.1016/j.neuron.2022.11.015
2. Yoshiko Nakamura, Takaki Yahiro, Akihiro Fukushima, Naoya Kataoka, Hiroyuki Hioki, Kazuhiro Nakamura. Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling. Science Advances, 2022; 8 (51) DOI: 10.1126/sciadv.add5463

Too much or too little light can cause serious problems for plants. Light levels are not simply a feast or famine equation when it comes to photosynthesis. Plants must carefully manage the amount of light coming in to ensure smooth photosynthesis. The way genes in leaves responding to rapidly changing light conditions help them make the most of photosynthesis.  Your eyes have to rapidly respond to opening curtains in a dark room, just like leaves of a plant. What about plants that have abandoned the need for light at all? Can a plant survive or thrive without light or photosynthesis? 

1. Thekla von Bismarck, Kübra Korkmaz, Jeremy Ruß, Kira Skurk, Elias Kaiser, Viviana Correa Galvis, Jeffrey A. Cruz, Deserah D. Strand, Karin Köhl, Jürgen Eirich, Iris Finkemeier, Peter Jahns, David M. Kramer, Ute Armbruster. Light acclimation interacts with thylakoid ion transport to govern the dynamics of photosynthesis in Arabidopsis. New Phytologist, 2022; 237 (1): 160 DOI: 10.1111/nph.18534
2. Kenji Suetsugu, Shun K. Hirota, Tian-Chuan Hsu, Shuichi Kurogi, Akio Imamura, Yoshihisa Suyama. Monotropastrum kirishimense (Ericaceae), a new mycoheterotrophic plant from Japan based on multifaceted evidence. Journal of Plant Research, 2022; DOI: 10.1007/s10265-022-01422-8

Peering into the history of brains with some amazing tiny fossils. How did the earliest brains develop? Is a head just an extension of a segmented body or something else entirely? How did the first brains and nervous systems evolve in arthropods. How does your body process the sense of touch? The faintest sensations of touch are handled by specialist cells in your spinal cord. How do your  brain stem and spinal cord help your body process the senses?

1. Nicholas J. Strausfeld, Xianguang Hou, Marcel E. Sayre, Frank Hirth. The lower Cambrian lobopodian Cardiodictyon resolves the origin of euarthropod brains. Science, 2022; 378 (6622): 905 DOI: 10.1126/science.abn6264
2. Turecek, J., Lehnert, B.P. & Ginty, D.D. The encoding of touch by somatotopically aligned dorsal column subdivisions. Nature, 2022 DOI: 10.1038/s41586-022-05470-x
3. Anda M. Chirila, Genelle Rankin, Shih-Yi Tseng, Alan J. Emanuel, Carmine L. Chavez-Martinez, Dawei Zhang, Christopher D. Harvey, David D. Ginty. Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain. Cell, 2022; 185 (24): 4541 DOI: 10.1016/j.cell.2022.10.012

Fungi have an amazing ability to spread across continents but stay linked as a family lineage. Fungi can adapt to specific geographic niches in the same way as grapes. Different families of highly specialized mushrooms grow side by side across continents. How can fungi protect the plants it's attached to? Fungi often get a bad rap in farming, but they can be used to detoxify soils. Removing mercury and boosting crops; is there anything fungi can't do?

1. Keaton Tremble, J. I. Hoffman, Bryn T. M. Dentinger. Contrasting continental patterns of adaptive population divergence in the holarctic ectomycorrhizal fungus Boletus edulis. New Phytologist, 2022; DOI: 10.1111/nph.18521
2. Congcong Wu, Dan Tang, Jin Dai, Xingyuan Tang, Yuting Bao, Jiali Ning, Qing Zhen, Hui Song, Raymond J. St. Leger, Weiguo Fang. Bioremediation of mercury-polluted soil and water by the plant symbiotic fungus Metarhizium robertsii. Proceedings of the National Academy of Sciences, 2022; 119 (47) DOI: 10.1073/pnas.2214513119

How is your gut connected to the rest of your body? How does your nervous system connect to your gut? How can you sense pain inside of your gut? The bacteria that live inside your gut can call for help when under pressure. With the wrong balance of bacteria or signalling proteins our guts can be more prone for inflammation and damage. How can bad bacteria escape from the gut and evade detection? What enables some bacteria to sneak out of the intestine and wreck havoc.

1. Wen Zhang, Mengze Lyu, Nicholas J. Bessman, Zili Xie, Mohammad Arifuzzaman, Hiroshi Yano, Christopher N. Parkhurst, Coco Chu, Lei Zhou, Gregory G. Putzel, Ting-Ting Li, Wen-Bing Jin, Jordan Zhou, Hongzhen Hu, Amy M. Tsou, Chun-Jun Guo, David Artis. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell, 2022; DOI: 10.1016/j.cell.2022.09.008
2. Yusibeska Ramos, Stephanie Sansone, Sung-Min Hwang, Tito A. Sandoval, Mengmeng Zhu, Guoan Zhang, Juan R. Cubillos-Ruiz, Diana K. Morales. Remodeling of the Enterococcal Cell Envelope during Surface Penetration Promotes Intrinsic Resistance to Stress. mBio, 2022; DOI: 10.1128/mbio.02294-22

How can fish keep themselves stable in a fast flowing river? What's the best way to stay on track as a fish? To swim straight ahead fish often end up staring downwards. The riverbed is way easier to track than a fast flowing current. How did fish manage to make their way into the deepest parts of the ocean? What climatic factors drove fish to explore deeper and deeper? What changed in Earth's history to encourage fish to thrive in the deepest parts of oceans?

1. Emma Alexander, Lanya T. Cai, Sabrina Fuchs, Tim C. Hladnik, Yue Zhang, Venkatesh Subramanian, Nicholas C. Guilbeault, Chinnian Vijayakumar, Muthukumarasamy Arunachalam, Scott A. Juntti, Tod R. Thiele, Aristides B. Arrenberg, Emily A. Cooper. Optic flow in the natural habitats of zebrafish supports spatial biases in visual self-motion estimation. Current Biology, 2022; DOI: 10.1016/j.cub.2022.10.009
2. Elizabeth Christina Miller, Christopher M. Martinez, Sarah T. Friedman, Peter C. Wainwright, Samantha A. Price, Luke Tornabene. Alternating regimes of shallow and deep-sea diversification explain a species-richness paradox in marine fishes. Proceedings of the National Academy of Sciences, 2022; 119 (43) DOI: 10.1073/pnas.2123544119

How have microbes changed the course of life on our planet? How has our atmosphere changed as a result of bacteria and archaea? Assimilation can help enhance single cellular life. Archaea can collect long strings of extra genes just in case. Finding the right gene at the right moment can help Archaea make the most of available food.

1. Basem Al-Shayeb, Marie C. Schoelmerich, Jacob West-Roberts, Luis E. Valentin-Alvarado, Rohan Sachdeva, Susan Mullen, Alexander Crits-Christoph, Michael J. Wilkins, Kenneth H. Williams, Jennifer A. Doudna, Jillian F. Banfield. Borgs are giant genetic elements with potential to expand metabolic capacity. Nature, 2022; DOI: 10.1038/s41586-022-05256-1

Ocean currents can have global impacts shaping our climate and life in the seas and onshore. How do the ocean currents circulate and vary not just on the surface but beneath the waves? It's easy to picture different layers of clouds, but the same is true for our oceans. Large circulating patterns of currents called Gyres govern the oceans. Tiny phytoplankton keep our oceans alive but how do they get enough food themselves? The middle of a gyre gets baked in sun and seems to lack nutrient sources, so how do microbes survive there? When phytoplankton die they rain down nutrients and carbon to lower layers of the ocean as marine snow.

1. Mukund Gupta, Richard G. Williams, Jonathan M. Lauderdale, Oliver Jahn, Christopher Hill, Stephanie Dutkiewicz, Michael J. Follows. A nutrient relay sustains subtropical ocean productivity. Proceedings of the National Academy of Sciences, 2022; 119 (41) DOI: 10.1073/pnas.2206504119

A big prize like the Nobel for Chemistry doesn't appear out of nowhere. To win a Nobel Prize, a lot of team work in laboratories and across the world has to come together. We find out about the research that led towards the Nobel Prize for chemistry and how it grew. How does Click Chemistry solve the problem of messy and complicated reactions? How do you look inside a cell when it's working without destroying it? How can you get precise tracking of cells behavior using Bioorthogonal chemistry.

1. Castelvecchi, D. and Ledford, H., 2022. Chemists who invented revolutionary ‘click’ reactions win Nobel. [online] Nature.com. Available at: [Accessed 8 October 2022].
2. Ramström, O., 2022. CLICK CHEMISTRY A N D BIOORTHOGONAL CHEMISTRY. [online] Nobelprize.org. Available at: [Accessed 8 October 2022].
3. Zhang, H., 2022. Nobel Prize: How click chemistry and bioorthogonal chemistry are transforming the pharmaceutical and material industries. [online] The Conversation. Available at: [Accessed 8 October 2022].

We celebrate the Ignobel prizes for 2022 with science that makes you laugh and then think. What connects a Fish, ducks and slipstream racing? How do mother ducks manage to keep all their ducklings in tow? Does swimming in formation help the ducks save energy? What's the best spot in the slipstream to be? We all know following in the slipstream is good, but if you're 3 or more back you can literally get pulled along. Complex fluid mechanics makes swimming in a line a way for a mother duck to pull the ducklings along. What happens physically when you find someone who is a good match? Is eye contact or heart rate a better measure of having  a 'spark' with someone new?

1. Wave-Riding and Wave-Passing by Ducklings in Formation Swimming,” Zhi-Ming Yuan, Minglu Chen, Laibing Jia, Chunyan Ji, and Atilla Incecik, Journal of Fluid Mechanics, vol. 928, no. R2, 2021.
2. “Energy Conservation by Formation Swimming: Metabolic Evidence from Ducklings,” Frank E. Fish, in the book Mechanics and Physiology of Animal Swimming, 1994, pp. 193-204.
3. Physiological Synchrony is Associated with Attraction in a Blind Date Setting,” Eliska Prochazkova, Elio Sjak-Shie, Friederike Behrens, Daniel Lindh, and Mariska E. Kret, Nature Human Behaviour, vol. 6, no. 2, 2022, pp. 269-278.

Mandarin oranges are very closely related but also incredibly diverse. A quirk of cloning means we can accurately trace the journey of all mandarins back to their origins in Hunan province. Mandarins come in so many shapes and sizes and are used to celebrate by many cultures, but they all share a lot in common. Oregano and Thyme both produce some great smells, but these chemicals can carry a useful punch. How do Oregano and Thyme produce chemicals with antibacterial properties?

1. Sandra T. Krause, Pan Liao, Christoph Crocoll, Benoît Boachon, Christiane Förster, Franziska Leidecker, Natalie Wiese, Dongyan Zhao, Joshua C. Wood, C. Robin Buell, Jonathan Gershenzon, Natalia Dudareva, Jörg Degenhardt. The biosynthesis of thymol, carvacrol, and thymohydroquinone in Lamiaceae proceeds via cytochrome P450s and a short-chain dehydrogenase. Proceedings of the National Academy of Sciences, 2021; 118 (52): e2110092118 DOI: 10.1073/pnas.2110092118
2. Guohong Albert Wu, Chikatoshi Sugimoto, Hideyasu Kinjo, Chika Azama, Fumimasa Mitsube, Manuel Talon, Frederick G. Gmitter, Daniel S. Rokhsar. Diversification of mandarin citrus by hybrid speciation and apomixis. Nature Communications, 2021; 12 (1) DOI: 10.1038/s41467-021-24653-0

Plants harness the energy from the sun for so much more than photosynthesis. You have a beating hart to pump around your blood, but what do plants. Plants' vascular systems aren't pressurized so how do they power their circulation? Just how much energy do plants use globally each year to pump water out of the ground and into their leaves? Plants use incredible amounts of energy each year just to pump water out of the ground into their leaves. The fresh scents of plants are organic compounds that can reveal a lot about a plants condition. The scents of plants can play a role in influencing the climate around them. 

1. Gregory R. Quetin, Leander D. L. Anderegg, Alexandra G. Konings, Anna T. Trugman. Quantifying the Global Power Needed for Sap Ascent in Plants. Journal of Geophysical Research: Biogeosciences, 2022; 127 (8) DOI: 10.1029/2022JG006922
2. Joseph Byron, Juergen Kreuzwieser, Gemma Purser, Joost van Haren, S. Nemiah Ladd, Laura K. Meredith, Christiane Werner, Jonathan Williams. Chiral monoterpenes reveal forest emission mechanisms and drought responses. Nature, 2022; 609 (7926): 307 DOI: 10.1038/s41586-022-05020-5

How can we develop new treatments to tackle antibiotic resistance and tumors. Antibiotics were the miracle of public health in the 20th century, but how can we establish new treatments into the 21st. Find the right protein and you can stop bacteria in its tracks by splitting it in two. New treatments can tackle antibiotic resistant bacteria by using proteins to break them in two. Cancer vaccines are benefiting from the mRNA revolution. A challenge with vaccines is that they can end up in the liver, so how do you get them to  deliver their instructions more effectively. Using special lipid nano particles, cancer mRNA vaccines can target the lymph nodes making for more powerful vaccines.

1. Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B. Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C. Reading, Gaetan Burgio, Si Ming Man. Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-32127-0
2. Jinjin Chen, Zhongfeng Ye, Changfeng Huang, Min Qiu, Donghui Song, Yamin Li, Qiaobing Xu. Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8 + T cell response. Proceedings of the National Academy of Sciences, 2022; 119 (34) DOI: 10.1073/pnas.2207841119

Wearable medical devices inside and outside of your body. Understanding what's happening inside your body can be tricky. Lugging around a scanning device with you all day isn't practical, but how can doctors tell what's happening in your daily life? Want to know what your organs are doing when you go for a jog or live your daily life? Wearable ultrasonic patches can give precise and long term ultrasounds making precise medicine possible. Stimulating nerves is a useful treatment for some conditions like Parkinson's or epilepsy but are very invasive. How can you use magnets to make these treatments much more friendly.

1. Chonghe Wang, Xiaoyu Chen, Liu Wang, Mitsutoshi Makihata, Hsiao-Chuan Liu, Tao Zhou, Xuanhe Zhao. Bioadhesive ultrasound for long-term continuous imaging of diverse organs. Science, 2022; 377 (6605): 517 DOI: 10.1126/science.abo2542
2. Joshua C. Chen, Peter Kan, Zhanghao Yu, Fatima Alrashdan, Roberto Garcia, Amanda Singer, C. S. Edwin Lai, Ben Avants, Scott Crosby, Zhongxi Li, Boshuo Wang, Michelle M. Felicella, Ariadna Robledo, Angel V. Peterchev, Stefan M. Goetz, Jeffrey D. Hartgerink, Sunil A. Sheth, Kaiyuan Yang, Jacob T. Robinson. A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves. Nature Biomedical Engineering, 2022; DOI: 10.1038/s41551-022-00873-7

How can we take ideas from nature and turn them upside down like growing plants without sunlight. There are some plants that thrive in 'low light' but what if they needed no light? Is it possible to change photosynthesis to work even without sunlight? Photosynthesis is great and all, but it's only around 1% efficient, so can it be improved? IF you were to make artificial photosynthesis can it outperform good ol natural sunlight? Biofilms are often the scourge of wearable devices, but what if they could help generate power? Turning sweat into electricity with bacteria could power your wearable devices.

1. Elizabeth C. Hann, Sean Overa, Marcus Harland-Dunaway, Andrés F. Narvaez, Dang N. Le, Martha L. Orozco-Cárdenas, Feng Jiao, Robert E. Jinkerson. A hybrid inorganic–biological artificial photosynthesis system for energy-efficient food production. Nature Food, 2022; 3 (6): 461 DOI: 10.1038/s43016-022-00530-x
2. Elizabeth C. Hann, Sean Overa, Marcus Harland-Dunaway, Andrés F. Narvaez, Dang N. Le, Martha L. Orozco-Cárdenas, Feng Jiao, Robert E. Jinkerson. A hybrid inorganic–biological artificial photosynthesis system for energy-efficient food production. Nature Food, 2022; 3 (6): 461 DOI: 10.1038/s43016-022-00530-x