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3Episodes
Category: Science

A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.

November 18, 2019

Episode 353 - Mysteries of plants, from using rare metals to boosting photosynthesis

Plants play an important role in our environment, yet there is still so much more to understand. We often think of nature as a zero sum game, but older and younger plants can collaborate. When surviving in a harsh environment, the best results occur when old and young plants grow together. Photosynthesis seems simple, but understanding the intricacies of the mechanisms can help us boost crop yields. Regulating the amount of photosynthesis can help plants survive or thrive in changing climates. How do boreal forests help capture nitrogen from the air? What does an odd metal have to do with forests in Canada storing nitrogen? 

  1. Alicia Montesinos-Navarro, Isabelle Storer, Rocío Perez-Barrales. Benefits for nurse and facilitated plants emerge when interactions are considered along the entire life-spanPerspectives in Plant Ecology, Evolution and Systematics, 2019; 41: 125483 DOI: 10.1016/j.ppees.2019.125483
  2. Lorna A. Malone, Pu Qian, Guy E. Mayneord, Andrew Hitchcock, David A. Farmer, Rebecca F. Thompson, David J. K. Swainsbury, Neil A. Ranson, C. Neil Hunter, Matthew P. Johnson. Cryo-EM structure of the spinach cytochrome b6 f complex at 3.6 Å resolutionNature, 2019; DOI: 10.1038/s41586-019-1746-6
  3. Princeton University. (2019, November 11). Nature's backup plan for converting nitrogen into plant nutrients. ScienceDaily. Retrieved November 15, 2019 from www.sciencedaily.com/releases/2019/11/191111180100.htm
November 11, 2019

Episode 352 - Figuring out where sound comes from and perceiving pitch

This week we look at the way our brains process sound, music, pitch and rhythm. How does our brain figure out where a sound is coming from? Do our eyes and ears process distance and location in a similar way? How does our brain discern differences in stimuli? What can we learn about pitch and rhythm from studying a remote Bolivian tribe? Is there a biological limit to our perception of sounds? Is our ability to perceive rhythm, chords and pitch cultural or biological?

References:

  1. Antje Ihlefeld, Nima Alamatsaz, Robert M Shapley. Population rate-coding predicts correctly that human sound localization depends on sound intensityeLife, 2019; 8 DOI: 10.7554/eLife.47027
  2. Nori Jacoby, Eduardo A. Undurraga, Malinda J. McPherson, Joaquín Valdés, Tomás Ossandón, Josh H. McDermott. Universal and Non-universal Features of Musical Pitch Perception Revealed by SingingCurrent Biology, 2019; DOI: 10.1016/j.cub.2019.08.020
October 21, 2019

Episode 349 - Domesticating fungus for our food

Humans have been using micro-organisms like fungus and bacteria to help improve our food for millennia. Can we tame new wild species of fungus to help create new types of our favourite foods like cheese? Penicillin is mostly known for antibiotics but it also helps give Camembert its particular taste. What causes cheese to rapidly tame wild strains of fungus? We are not the only ones who use microbes to help our food. Ants help stop disease from destroying plants by spreading their own antibiotics. Ant base antibiotics help stop plant pathogens. Sometimes bacteria don't fight against each other but rather team up and work together. Survival of kindest rules for bacteria, which helps different strains work together to survive.

References:

  1. Bodinaku, I., Shaffer, J., Connors, A. B., Steenwyk, J. L., Biango-Daniels, M. N., Kastman, E. K., … Wolfe, B. E. (2019). Rapid Phenotypic and Metabolomic Domestication of Wild Penicillium Molds on Cheese. MBio, 10(5). doi: 10.1128/mbio.02445-19
  2. Joachim Offenberg, Christian Damgaard. Ants suppressing plant pathogens: a review. Oikos, 2019; DOI: 10.1111/oik.06744
  3. Wenzheng Liu, Samuel Jacquiod, Asker Brejnrod, Jakob Russel, Mette Burmølle, Søren J. Sørensen. Deciphering links between bacterial interactions and spatial organization in multispecies biofilms. The ISME Journal, 2019; DOI: 10.1038/s41396-019-0494-9
October 7, 2019

Episode 347 - Capturing carbon with better farms and forests

Capturing carbon is important for helping offset CO2 emissions and tackling climate changes. Farming has an important role to play in improving CO2 sequestration with the use of cover crops and compost. Forests are important carbon sinks too, but they are at risk releasing a lot of the trapped carbon if care is not taken to stop invasive species. Plus fertilisers have helped feed the planet but can leech out nitrogen into the environment, so how do we better manage and improve the nitrogen cycle.

  1. Nicole E. Tautges, Jessica L. Chiartas, Amélie C. M. Gaudin, Anthony T. O'Geen, Israel Herrera, Kate M. Scow. Deep soil inventories reveal that impacts of cover crops and compost on soil carbon sequestration differ in surface and subsurface soilsGlobal Change Biology, 2019; DOI: 10.1111/gcb.14762
  2. Songlin Fei, Randall S. Morin, Christopher M. Oswalt, Andrew M. Liebhold. Biomass losses resulting from insect and disease invasions in US forestsProceedings of the National Academy of Sciences, 2019; 201820601 DOI: 10.1073/pnas.1820601116
  3. Benjamin Z. Houlton, Maya Almaraz, Viney Aneja, Amy T. Austin, Edith Bai, Kenneth G. Cassman, Jana E. Compton, Eric A. Davidson, Jan Willem Erisman, James N. Galloway, Baojing Gu, Guolin Yao, Luiz A. Martinelli, Kate Scow, William H. Schlesinger, Thomas P. Tomich, Chao Wang, Xin Zhang. A World of Cobenefits: Solving the Global Nitrogen ChallengeEarth's Future, 2019; DOI: 10.1029/2019EF001222
September 30, 2019

Episode 346 - Can washing machines help stop microplastics in oceans and make hospitals safer

Washing machines can save a lot of time and help clean up mess, but they can also harm our health and environment. Which washing process is better for the environment - full an fast or empty and delicate? How do washing machines help fill our oceans with microplastics? What can be done to help stop washing machines contributing to the microplastics in our waterways? Which washing setting is best for your health? Cold and clean or warm and soapy? How did a normal washing machine cause havoc in a hospital? How can you multi-drug resistant pathogens spread through a washing machine? 

References:

  1. American Society for Microbiology. (2019, September 27). Your energy-efficient washing machine could be harboring pathogens: Lower temperatures used in 'energy saver' washing machines may not be killing all pathogens. ScienceDaily. Retrieved September 29, 2019 from www.sciencedaily.com/releases/2019/09/190927135202.htm
  2. Max R. Kelly, Neil J. Lant, Martyn Kurr, J. Grant Burgess. Importance of Water-Volume on the Release of Microplastic Fibers from LaundryEnvironmental Science & Technology, 2019; DOI: 10.1021/acs.est.9b03022
September 23, 2019

Episode 345 - Overactive immune brain cells and brain cells failing to eat themselves

Is it possible to stop Alzheimer's in it's tracks? How does the formation of plaques on your brain cells lead to Alzheimer's. Does the your brain immune cells fighting back against plaques lead to Alzheimers? Amino acids in the brain tying themselves into knots, can lead to super strong sealed zippers forming which dry out proteins, damage neurons and eventually can lead to diseases like Alzheimer's. An enzyme missing a repair or two over 60 years can lead to build up of kinked amino acids chains which can lead to neuron-degenerative diseases. What causes a cell to eat itself? Well its actually a pretty healthy thing to do. If a brain cell doesn't eat itself at the right time, well it can lead to a whole bunch of diseases.

  1. Rebeccah A. Warmack, David R. Boyer, Chih-Te Zee, Logan S. Richards, Michael R. Sawaya, Duilio Cascio, Tamir Gonen, David S. Eisenberg, Steven G. Clarke. Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interfaceNature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11183-z
  2. Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease modelNature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11674-z
  3. Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress responseNature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11671-2
September 9, 2019

Episode 343 - The circadian rhythm of plants, and fighting back against fungus

Growing enough food to feed the planet is a challenge that will only get harder as the climate changes. So how do farmers and scientists work together to make crops more sustainable, more resilient to disease, and use less herbicides? With genetic engineering, one of the worlds most important crops, rice, can be made even tougher. Using a two type bait gene, rice can be engineered to fight off fungus like rice blast. If you have to spray with herbicides, when should you do it? Well you need to pay attention to the circadian rhythm of the plants.

  1. Freya A Varden, Hiromasa Saitoh, Kae Yoshino, Marina Franceschetti, Sophien Kamoun, Ryohei Terauchi, Mark J. Banfield. Cross-reactivity of a rice NLR immune receptor to distinct effectors from the rice blast pathogen Magnaporthe oryzae provides partial disease resistanceJournal of Biological Chemistry, 2019; jbc.RA119.007730 DOI: 10.1074/jbc.RA119.007730
  2. Fiona E. Belbin, Gavin J. Hall, Amelia B. Jackson, Florence E. Schanschieff, George Archibald, Carl Formstone, Antony N. Dodd. Plant circadian rhythms regulate the effectiveness of a glyphosate-based herbicideNature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11709-5
August 26, 2019

Episode 341 - Forming, Saving and preserving new memories

Your brain uses proteins synthesis and redundancy to help form and keep memories. Intricate biochemistry helps your neurons connect to each other to form new memories. Forming new memories is a sticky situation.  Keeping them stuck together over time in a long lasting memory relies on protein synthesis. Its important not just to have strong connections between neurons to form memories, you also need spares. By having redundancy and backups it means that you can still remember a key memory if one of those connections fails.

References

  1. Lenzie Ford et al. CPEB3 inhibits translation of mRNA targets by localizing them to P bodiesPNAS, 2019 DOI: 10.1073/pnas.1815275116
  2. Walter G. Gonzalez, Hanwen Zhang, Anna Harutyunyan, Carlos Lois. Persistence of neuronal representations through time and damage in the hippocampusScience, 2019: Vol. 365, Issue 6455, pp. 821-825 DOI: 10.1126/science.aav9199
August 19, 2019

Episode 340 - Insects revolutionizing agriculture

Insects are often thought of as the enemy of farmers, but they can help improve farming. From helpful worm pheromones, to farming crickets and hungry termites. Worms can help boost the resilience of crops like wheat, corn and maize to common threats. Worm pheromones help plants fight back against bacteria, viral and fungal invaders. If insects are the super food of the future, how do you successfully farm them on a large scale? What nutrient rich feed do insect farms need to give their herds? If you are growing crickets and locusts do they need different food? What food is best for termites and how can they be used to help better manage forest?

References:

  1. Daniel F. Klessig, Murli Manohar, Shine Baby, Aline Koch, Wiseborn B. Danquah, Emily Luna, Hee‐Jin Park, Judith M. Kolkman, B. Gillian Turgeon, Rebecca Nelson, Jan E. Leach, Valerie M. Williamson, Karl‐Heinz Kogel, Aardra Kachroo, Frank C. Schroeder. Nematode ascaroside enhances resistance in a broad spectrum of plant–pathogen systems. Journal of Phytopathology, 2019; 167 (5): 265 DOI: 10.1111/jph.12795
  2. P. Straub, C.M. Tanga, I. Osuga, W. Windisch, S. Subramanian. Experimental feeding studies with crickets and locusts on the use of feed mixtures composed of storable feed materials commonly used in livestock production. Animal Feed Science and Technology, 2019; 255: 114215 DOI: 10.1016/j.anifeedsci.2019.114215
  3. Martin F. Jurgensen, Chris A. Miller, Carl T. Trettin, Deborah S. Page-Dumroese. Bedding of Wetland Soil: Effects of Bed Height and Termite Activity on Wood Decomposition. Soil Science Society of America Journal, 2019; 0 (0): 0 DOI: 10.2136/sssaj2018.12.0492
August 12, 2019

Episode 339 - Australian Science - life on gold, in the oceans and in deadly gas

To celebrate National Science Week in Australia we are turning our attention to Australian research on the global scale. This week it means tales from microbiology. Stories of how life can survive or sometimes thrive in strange situations. Whether it be Fungi that eat gold, or bacteria chewing deadly gas, microbiology is always full of surprises. How do the tiniest parts of the food-web of our oceans hunt for food in the swirling of stagnant currents of the ocean? How do bacteria turn deadly gas into a food source? Is the secret to tuberculosis's resistance its ability to survive off deadly gas? How do bacteria turn carbon monoxide and hydrogen into something palatable?

References:

  1. Cordero, P. R., Bayly, K., Leung, P. M., Huang, C., Islam, Z. F., Schittenhelm, R. B., . . . Greening, C. (2019). Atmospheric carbon monoxide oxidation is a widespread mechanism supporting microbial survival. The ISME Journal. doi:10.1038/s41396-019-0479-8
  2. Islam, Z. F., Cordero, P. R., Feng, J., Chen, Y., Bay, S. K., Jirapanjawat, T., . . . Greening, C. (2018). Two Chloroflexi classes independently evolved the ability to persist on atmospheric hydrogen and carbon monoxide. The ISME Journal. doi:10.1101/457697
  3. Lehmann, E. (n.d.). Gold-coated fungi are the new gold diggers. Retrieved from https://www.csiro.au/en/News/News-releases/2019/Gold-coated-fungi-are-the-new-gold-diggers
  4. Bohu, T., Anand, R., Noble, R., Lintern, M., Kaksonen, A. H., Mei, Y., . . . Verrall, M. (2019). Evidence for fungi and gold redox interaction under Earth surface conditions. Nature Communications, 10(1). doi:10.1038/s41467-019-10006-5
  5. Holland, D., & University of Melbourne. (2019, August 05). The superheroes of nutrient detection living in our oceans. Retrieved from https://pursuit.unimelb.edu.au/articles/the-superheroes-of-nutrient-detection-living-in-our-oceans#
  6. Brumley, D. R., Carrara, F., Hein, A. M., Yawata, Y., Levin, S. A., & Stocker, R. (2019). Bacteria push the limits of chemotactic precision to navigate dynamic chemical gradients. Proceedings of the National Academy of Sciences, 116(22), 10792-10797. doi:10.1073/pnas.1816621116
July 29, 2019

Lagrange Point Episode 337 - Stopping deforestation, saving species and conservation

As the climate changes different species are at risk. Some will thrive and others will struggle, so how do we target conservation efforts to better protect at risk species? Deforestation is a big issue in developing countries, but is there a win-win for the population and the planet? When sea levels rise, we think about flooding and erosion, but not what will happen to the forests and birds who live in them. Trees in the city live fast and die young, which means we need a whole new set of forest management techniques.

References:

  1. Paul J. Taillie, Christopher E. Moorman, Lindsey S. Smart, Krishna Pacifici. Bird community shifts associated with saltwater exposure in coastal forests at the leading edge of rising sea levelPLOS ONE, 2019; 14 (5): e0216540 DOI: 10.1371/journal.pone.0216540
  2. C. David L. Orme, Sarah Mayor, Luiz dos Anjos, Pedro F. Develey, Jack H. Hatfield, José Carlos Morante-Filho, Jason M. Tylianakis, Alexandre Uezu, Cristina Banks-Leite. Distance to range edge determines sensitivity to deforestationNature Ecology & Evolution, 2019; DOI: 10.1038/s41559-019-0889-z
  3. Ian A. Smith, Victoria K. Dearborn, Lucy R. Hutyra. Live fast, die young: Accelerated growth, mortality, and turnover in street treesPLOS ONE, 2019; 14 (5): e0215846 DOI: 10.1371/journal.pone.0215846
  4. Johan A. Oldekop, Katharine R. E. Sims, Birendra K. Karna, Mark J. Whittingham, Arun Agrawal. Reductions in deforestation and poverty from decentralized forest management in NepalNature Sustainability, 2019; DOI: 10.1038/s41893-019-0277-3
July 14, 2019

Episode 335 - Oceans, ocean size algae, deserts and fresh water in strange places

Water, water everywhere but not a drop to drink or nutrient for that matter. The Ocean can sometimes be a inhospitable place with barely any nutrients to survive off. Other times it can be home to large ocean spanning algae blooms. The oceans from the Pacific to the Atlantic can hold lots of secrets (even fresh water) beneath the surface. This week we look at 3 different papers which outline strange parts of the ocean, from large algae blooms to hidden aquifers.

References:

  1. Greta Reintjes, Halina E. Tegetmeyer, Miriam Bürgisser, Sandi Orlić, Ivo Tews, Mikhail Zubkov, Daniela Voß, Oliver Zielinski, Christian Quast, Frank Oliver Glöckner, Rudolf Amann, Timothy G. Ferdelman, Bernhard M. Fuchs. On-Site Analysis of Bacterial Communities of the Ultraoligotrophic South Pacific Gyre. Applied and Environmental Microbiology, 2019; 85 (14) DOI: 10.1128/AEM.00184-19
  2. Mengqiu Wang, Chuanmin Hu, Brian B. Barnes, Gary Mitchum, Brian Lapointe, Joseph P. Montoya. The great Atlantic Sargassum belt. Science, 2019; 365 (6448): 83 DOI: 10.1126/science.aaw7912
  3. Chloe Gustafson, Kerry Key, Rob L. Evans. Aquifer systems extending far offshore on the U.S. Atlantic margin. Scientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-44611-7
June 30, 2019

Episode 333 - Saving which bees and where

Saving the bees has gotten widespread understanding, but it is more nuanced than a simple sound bite. Which bees are in danger and where? How many bee species are out there and are under threat? Can domesticated bees spread disease to wild populations? How do wild flowers help feed bees but also spread disease? Can different types of crop cycles help both wild and domesticated bees thrive? We know of colony collapse disorder and pesticides, but what other threats are out there to bee populations? Does the urban sprawl play a role in destabilising the gender balance of the bee populations? Why do bee populations drop off as you approach the city?

References:

  1. Samantha A. Alger, P. Alexander Burnham, Humberto F. Boncristiani, Alison K. Brody. RNA virus spillover from managed honeybees (Apis mellifera) to wild bumblebees (Bombus spp.). PLOS ONE, 2019; 14 (6): e0217822 DOI: 10.1371/journal.pone.0217822
  2. Dimitry Wintermantel, Jean-François Odoux, Joël Chadœuf, Vincent Bretagnolle. Organic farming positively affects honeybee colonies in a flower-poor period in agricultural landscapes. Journal of Applied Ecology, 2019; DOI: 10.1111/1365-2664.13447
  3. Gordon Fitch, Paul Glaum, Maria-Carolina Simao, Chatura Vaidya, Jill Matthijs, Benjamin Iuliano, Ivette Perfecto. Changes in adult sex ratio in wild bee communities are linked to urbanization. Scientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-39601-8
June 10, 2019

Episode 330 - A cells journey, from birth to death

This week we dive into the complicated history of cells and try to figure out if you are still the same ship. How does a cell know what it wants to grow up to be? What helps it make the decision to be an optic nerve, a neuron or part of your jawbone? How old are all the cells in your body? Are they all the same age, and what does age even mean anyway? This week we dive into the complicated history of cells and try to figure out if you are still the same ship. 

References:

  1. Rafael Arrojo e Drigo, Varda Lev-Ram, Swati Tyagi, Ranjan Ramachandra, Thomas Deerinck, Eric Bushong, Sebastien Phan, Victoria Orphan, Claude Lechene, Mark H. Ellisman, Martin W. Hetzer. Age Mosaicism across Multiple Scales in Adult Tissues. Cell Metabolism, 2019; DOI: 10.1016/j.cmet.2019.05.010
  2. Ruslan Soldatov, Marketa Kaucka, Maria Eleni Kastriti, Julian Petersen, Tatiana Chontorotzea, Lukas Englmaier, Natalia Akkuratova, Yunshi Yang, Martin Häring, Viacheslav Dyachuk, Christoph Bock, Matthias Farlik, Michael L. Piacentino, Franck Boismoreau, Markus M. Hilscher, Chika Yokota, Xiaoyan Qian, Mats Nilsson, Marianne E. Bronner, Laura Croci, Wen-Yu Hsiao, Jean-Francois Brunet, Gian Giacomo Consalez, Patrik Ernfors, Kaj Fried, Peter V. Kharchenko, Igor Adameyko. Spatiotemporal structure of cell fate decisions in murine neural crest. Science, 2019; 364 (6444): eaas9536 DOI: 10.1126/science.aas9536
May 20, 2019

Episode 327 - Hippos and Algae, Lions and Porcupines, plus Narwhals.

What connects Hippos, Algae and keeping the rivers of Africa healthy? What causes Lions to square-off against Porcupines? What is keeping the Narwhal population healthy despite it's genetic diversity? We look at the strange interconnection between species and how small changes in one ecosystem can destabilise a whole species.

Hippos help keep the rivers and lakes of Africa healthy...through their poo.

Hippos are essential in pumping silicon from the savannah into the rivers and lakes of Africa.

Lions hunt lots of creatures, but what needs to happen for them to try attacking a Porcupine?

Porcupines vs Lion sounds like a March Mammal Madness battle, but what causes a Lion to go after such a tough prey?

The Narwhals population is rebounding but it its still at risk due to it's shallow gene pool.

Can a species survive with a shallow gene pool?

References:

  1. Schoelynck, J., Subalusky, A.L., Struyf, E., Dutton, C.L., Unzué-Belmonte, D., Van de Vijver, B., Post, D.M., Rosi, E.J., Meire, P., Frings, P. Hippos (Hippopotamus amphibius): The animal silicon pumpScience Advances, 2019 DOI: 10.1126/sciadv.aav0395
  2. Julian C. Kerbis Peterhans, Gastone G. Celesia, Thomas P. Gnoske. Lion-Porcupine Interactions in Africa, Including Impacts on Lion Predatory BehaviorJournal of East African Natural History, 2019; 108 (1): 1 DOI: 10.2982/028.108.0101
  3. Westbury, M.V. Narwhal genome reveals long-term low genetic diversity despite current large abundance sizeiScience, 2019 DOI: 10.1016/j.isci.2019.03.023
May 6, 2019

Episode 325 - Racing against time, from Box Jellyfish to Alzheimers

Medicine is often a race against time, to diagnose, to develop and to treat. This week we're looking at new research which speeds up the detection of Alzheimers in patients and provides a chance to test out potential treatments. We also find out how University of Sydney researchers may help deliver a quick antivenom to those stung by the deadly box jellyfish. Plus ways to turn leftover bits of junk in blood plasma, into useful diagnosis tools that may help save time and lives in treatment without wasting more time on tests.

References:

  1. Man-Tat Lau, John Manion, Jamie B. Littleboy, Lisa Oyston, Thang M. Khuong, Qiao-Ping Wang, David T. Nguyen, Daniel Hesselson, Jamie E. Seymour, G. Gregory Neely. Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-09681-1
  2. Maria D Giraldez, Ryan M Spengler, Alton Etheridge, Annika J Goicochea, Missy Tuck, Sung Won Choi, David J Galas, Muneesh Tewari. Phospho-RNA-seq: a modified small RNA-seq method that reveals circulating mRNA and lncRNA fragments as potential biomarkers in human plasma. EMBO Journal, 2019 DOI: 10.15252/embj.2019101695
  3. Andreas Nabers, Henning Hafermann, Jens Wiltfang, Klaus Gerwert. Aβ and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019; 11: 257 DOI: 10.1016/j.dadm.2019.01.008

Medicine is often a race against time, to diagnose, to develop and to treat. This week it's stories of scientists and doctors racing against the clock.

New research which speeds up the detection of Alzheimer's in patients and provides a chance to test out potential treatments.

We find out how University of Sydney researchers may help deliver a quick antivenom to those stung by the deadly box jellyfish.

Plus ways to turn leftover bits of junk in blood plasma, into useful diagnosis tools that may help save time and lives in treatment without wasting more time on tests.

There are whole bundles of random RNA fragments in blood plasma, but these can be used to help diagnose specific issues.

The box jellyfish is just one of the many things in Australia that is trying to kill you, but now it's slightly less deadly thanks to University of Sydney researchers.

April 22, 2019

Lagrange Point Episode 323 - Keeping your immune system in fighting shape

How can we keep our immune systems in fighting shape? What happens when our immune systems are responding well or are missing key genes? is there targeted gene therapies that can be used to help save lives of those most at risk from infection?  How does our body hunt down and stop Listeria in it's tracks? Plus undercooked wild game or pork can lead to parasitic infections, but how does the body fight back?

References:

  1. E Mamcarz et al. Lentiviral gene therapy with low dose busulfan for infants with X-SCIDThe New England Journal of Medicine, April 17, 2019; DOI: 10.1056/NEJMoa1815408
  2. Kazuhito Sai, Cameron Parsons, John S. House, Sophia Kathariou, Jun Ninomiya-Tsuji. Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killingThe Journal of Cell Biology, 2019; jcb.201810014 DOI: 10.1083/jcb.201810014
  3. Nicola Steel, Aduragbemi A. Faniyi, Sayema Rahman, Stefanie Swietlik, Beata I. Czajkowska, Bethany T. Chan, Alexander Hardgrave, Anthony Steel, Tim D. Sparwasser, Mushref B. Assas, Richard K. Grencis, Mark A. Travis, John J. Worthington. TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in micePLOS Pathogens, 2019; 15 (4): e1007657 DOI: 10.1371/journal.ppat.1007657
April 1, 2019

Episode 320 - Extinction events and their causes

Life has been around on earth for a long time, but there have been many extinction events that have wiped out large numbers of species. This week we find out how scientists peel back the layers of rock to uncover what caused these extinction events. Plus we find out about current extinction events and what we can learn from the past to protect species today.

References:

  1. DePalma, Robert A.; Smit, Jan; Burnham, David; Kuiper, Klaudia; Manning, Phillip; Oleinik, Anton; Larson, Peter; Maurrasse, Florentin; Vellekoop, Johan; Richards, Mark A.; Gurche, Loren; Alvarez, Walter. Prelude to Extinction: a seismically induced onshore surge deposit at the KPg boundary, North DakotaPNAS, 2019
  2. Ben C. Scheele et al. Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversityScience, 2019 DOI: 10.1126/science.aav0379
  3. Seth A. Young, Andrew Kleinberg, Jeremy D. Owens. Geochemical evidence for expansion of marine euxinia during an early Silurian (Llandovery–Wenlock boundary) mass extinctionEarth and Planetary Science Letters, 2019; 513: 187 DOI: 10.1016/j.epsl.2019.02.023
March 18, 2019

Episode 318 - Stubborn Moose, repulsive smells and Otters with tools

We recap March Mamma Madness Round 1, and look at some latest science stories that relate. From what happens inside your brain when you smell a repulsive smell, to making the right call on fleeing or standing your ground. Plus we look at using archaeological techniques to help understand the history of animal tool use like with otters. 

References:

  1. Ahmed A. M. Mohamed, Tom Retzke, Sudeshna Das Chakraborty, Benjamin Fabian, Bill S. Hansson, Markus Knaden, Silke Sachse. Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobeNature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-09069-1
  2. Michael Haslam, Jessica Fujii, Sarah Espinosa, Karl Mayer, Katherine Ralls, M. Tim Tinker, Natalie Uomini. Wild sea otter mussel pounding leaves archaeological tracesScientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-39902-y
  3. B. A. Oates, J. A. Merkle, M. J. Kauffman, S. R. Dewey, M. D. Jimenez, J. M. Vartanian, S. A. Becker, J. R. Goheen. Antipredator response diminishes during periods of resource deficit for a large herbivoreEcology, 2019; e02618 DOI: 10.1002/ecy.2618
March 4, 2019

Episode 316 - Mice that sing and see in infrared, balancing predators and 2019MMM Preview

We preview 2019 March Mammal Madness, and find out about interesting animals from across the world. We look at ways to augment vision to help see in infra-red, and use singing mice to study human conversation. Plus we find out about balancing predators and prey.

References:

  1. March Mammal Madness
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