Episode 373 - Deep sea reefs, ocean vents and tiny life

This week we look at unlikely partnerships that help sea creatures survive and thrive. What plays a crucial role inside a reef's ecosystem that is often overlooked? What's inside fish guts that help keep a reef healthy? Just how do fish 1000s of kms away end up with the same colonies of microbes? Feel like a tasty snack but stuck in the deep ocean vents, why not methane? How do microbes help worms eat methane? 

1. Shana Goffredi et al. Methanotrophic bacterial symbionts fuel dense populations of deep-sea feather duster worms (Sabellida, Annelida) and extend the spatial influence of methane seepage. Science Advances, 2020 DOI: 10.1126/sciadv.aay8562
2. Jarrod J. Scott, Thomas C. Adam, Alain Duran, Deron E. Burkepile, Douglas B. Rasher. Intestinal microbes: an axis of functional diversity among large marine consumers. Proceedings of the Royal Society B: Biological Sciences, 2020; 287 (1924): 20192367 DOI: 10.1098/rspb.2019.2367

Episode 371 - Marine Mammals vs Parasites

Its a battle between Marine Mammals and Parasites. How does an opossum parasite start killing sea otters?  In #2020MMM unexpected combatants can ruin your day, just like how opossum parasites are taking out sea otters. How does a parasite make a long journey from land to end up out at sea? Inside raw fish, parasitic worm populations are booming. This is bad news for marine mammals. Conserving marine mammals can be a delicate balancing act as parasite populations can also start to thrive.

1. Tristan L. Burgess, M. Tim Tinker, Melissa A. Miller, Woutrina A. Smith, James L. Bodkin, Michael J. Murray, Linda M. Nichol, Justin A. Saarinen, Shawn Larson, Joseph A. Tomoleoni, Patricia A. Conrad, Christine K. Johnson. Spatial epidemiological patterns suggest mechanisms of land-sea transmission for Sarcocystis neurona in a coastal marine mammaTl. Scientific Reports, 2020; 10 (1) DOI: 10.1038/s41598-020-60254-5
2. Evan A. Fiorenza, Catrin A. Wendt, Katie A. Dobkowski, Teri L. King, Marguerite Pappaionou, Peter Rabinowitz, Jameal F. Samhouri, Chelsea L. Wood. It’s a wormy world: Meta-analysis reveals several decades of change in the global abundance of the parasitic nematodes Anisakis spp. and Pseudoterranova spp. in marine fishes and invertebrates. Global Change Biology, 2020; DOI: 10.1111/gcb.15048

Episode 368 - Brain injuries, epilepsy and treatment options

How can we give better quality of life for those suffering from neurological conditions? Getting a concussion is bad enough, but why do people often develop epilepsy afterwards? What is the link between concussions and epilepsy? How can we effectively reduce the risk of epilepsy after a concussion? For certain epilepsy conditions in children, CBD can help reduce seizure risk, but what type is best? Is pharmaceutical or artisan CBD for children with epilepsy?

1. Akshata A. Korgaonkar, Ying Li, Dipika Sekhar, Deepak Subramanian, Jenieve Guevarra, Bogumila Swietek, Alexandra Pallottie, Sukwinder Singh, Kruthi Kella, Stella Elkabes, Vijayalakshmi Santhakumar. Toll‐like Receptor 4 Signaling in Neurons Enhances Calcium‐Permeable α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Receptor Currents and Drives Post‐Traumatic Epileptogenesis. Annals of Neurology, 2020; DOI: 10.1002/ana.25698
2. American Academy of Neurology. (2020, February 27). Artisanal CBD not as effective as pharmaceutical CBD for reducing seizures. ScienceDaily. Retrieved February 29, 2020 from www.sciencedaily.com/releases/2020/02/200227160545.htm

Episode 365 - Wasps, Bees, tasty meals and pesticide.

From wasps to bees how are insects adapting to a changing world. What type of food do bees prefer? Can a bee be a fussy eater? What makes a tasty meal for a Bee and what would they avoid like the plague? What changes can be introduced into the microbiome by pesticides? How can pesticides change the microbiome of wasps and develop into resistance? Can pesticide actually make lives harder for themselves by building tolerance in insects? How does an Asian hornet end up in Northern Europe?

1. Wang et al. Changes in microbiome confer multigenerational host resistance after sub-toxic pesticide exposure. Cell Host & Microbe, 2020 DOI: 10.1016/j.chom.2020.01.009
2. Martin Husemann, Andreas Sterr, Swen Mack, Rudolf Abraham. The northernmost record of the Asian hornet Vespa velutina nigrithorax (Hymenoptera, Vespidae). Evolutionary Systematics, 2020; 4 (1): 1 DOI: 10.3897/evolsyst.4.47358
3. Fabian A. Ruedenauer, David Raubenheimer, Daniela Kessner‐Beierlein, Nils Grund‐Mueller, Lisa Noack, Johannes Spaethe, Sara D. Leonhardt. Best be(e) on low fat: linking nutrient perception, regulation and fitness. Ecology Letters, 2020; DOI: 10.1111/ele.13454

Episode 364 - Coronavirus from SARS to MERs and nConv2019

The Coronavirus family is a dangerous lot from SARS to MERS and Novel Coronavirus 2019. This week we look at the history of Coronavirus outbreaks, research into past infections and public health strategy. We do some fact checking on Coronavirus myths and fears. What lessons were learnt from the SARS outbreak of '03 that can help today in '20? How can turning off the cells recycling plant stop Coronaviruses in their tracks? What role does cell autophagy play in spreading or stopping MERS? What can we learn from the sequenced genomes of coronaviruses? How can tracking the ACE2 gene help people monitor the mutation of the coronavirus strains?

1. Lewis, D. (2020). Coronavirus outbreak: what’s next? Nature. doi: 10.1038/d41586-020-00236-9
2. Hollingsworth, J. (2020, January 30). The memory of SARS looms over the Wuhan virus. Here's how the outbreaks compare. Retrieved from https://edition.cnn.com/2020/01/29/china/sars-wuhan-virus-explainer-intl-hnk-scli/index.html
3. Alerts - Novel coronavirus - Frequently asked questions. (n.d.). Retrieved from https://www.health.nsw.gov.au/Infectious/alerts/Pages/coronavirus-faqs.aspx#1-1
4. Coronavirus latest: WHO declares global emergency. (2020, January 30). Retrieved from https://www.nature.com/articles/d41586-020-00154-w
5. Yushun Wan, Jian Shang, Rachel Graham, Ralph S. Baric, Fang Li. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology, 2020; DOI: 10.1128/JVI.00127-20
6. Nils C. Gassen, Daniela Niemeyer, Doreen Muth, Victor M. Corman, Silvia Martinelli, Alwine Gassen, Kathrin Hafner, Jan Papies, Kirstin Mösbauer, Andreas Zellner, Anthony S. Zannas, Alexander Herrmann, Florian Holsboer, Ruth Brack-Werner, Michael Boshart, Bertram Müller-Myhsok, Christian Drosten, Marcel A. Müller, Theo Rein. SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-13659-4

Episode 363 - Mysteries from underwater volcanoes

There are mysterious things lurking at the bottom of the ocean, from underwater volcanoes to mysterious graphite. Where did a pumice raft floating across the Pacific come from? Why is a raft of pumice larger than Manhattan heading to Australia? What can we learn by studying petit-spot volcanoes underneath the ocean? What connects young volcanoes with the motion of the tectonic plates? What roll do hydrothermal vents play in the carbon cycle? Where does all this graphite in the oceans come from?

1. Philipp A. Brandl, Florian Schmid, Nico Augustin, Ingo Grevemeyer, Richard J. Arculus, Colin W. Devey, Sven Petersen, Margaret Stewart, Heidrun Kopp, Mark D. Hannington. The 6–8 Aug 2019 eruption of ‘Volcano F’ in the Tofua Arc, Tonga. Journal of Volcanology and Geothermal Research, 2019; 106695 DOI: 10.1016/j.jvolgeores.2019.106695
2. Naoto Hirano, Shiki Machida, Hirochika Sumino, Kenji Shimizu, Akihiro Tamura, Taisei Morishita, Hideki Iwano, Shuhei Sakata, Teruaki Ishii, Shoji Arai, Shigekazu Yoneda, Tohru Danhara, Takafumi Hirata. Petit-spot volcanoes on the oldest portion of the Pacific plate. Deep Sea Research Part I: Oceanographic Research Papers, 2019; 154: 103142 DOI: 10.1016/j.dsr.2019.103142
3. Harry MacKay, C. Anthony Scott, Jack D. Duryea, Maria S. Baker, Eleonora Laritsky, Amanda E. Elson, Theodore Garland, Marta L. Fiorotto, Rui Chen, Yumei Li, Cristian Coarfa, Richard B. Simerly, Robert A. Waterland. DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-13339-3

Episode 362 - Life after a disaster from Fukashima to Chernobyl

What happens next after disaster strikes and people flee for safety? How do wildlife move in when people move out of a disaster zone? How do animals moving into an evacuated area change with no humans around? What is the most effective thing to do if you live near a disaster area? How do we assess risk and life expectancy impact of living near a disaster zone? Is it more dangerous to live near a nuclear plant or in the diesel smog of the big city?

1. Phillip C Lyons, Kei Okuda, Matthew T Hamilton, Thomas G Hinton, James C Beasley. Rewilding of Fukushima's human evacuation zone. Frontiers in Ecology and the Environment, 2020; DOI: 10.1002/fee.2149
2. Philip Thomas, John May. Coping after a big nuclear accident. Process Safety and Environmental Protection, 2017; 112: 1 DOI: 10.1016/j.psep.2017.09.013

Episode 360 - Imaging hard-working Cells keeping you alive during illness

How do we peer into the inner workings of our cells, especially during their response to a medical emergency? What role does fibroblasts play to protect your heart after a heart attack? When is your body hardest at work repairing damage after a heart attack? What stem cells control your blood cells? How can we get a picture of the complex 3D shape of blood stem cells in your bone marrow? What role does bone marrow play in blood regulation?
References:

1. Chiara Baccin, Jude Al-Sabah, Lars Velten, Patrick M. Helbling, Florian Grünschläger, Pablo Hernández-Malmierca, César Nombela-Arrieta, Lars M. Steinmetz, Andreas Trumpp, Simon Haas. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nature Cell Biology, 2019; DOI: 10.1038/s41556-019-0439-6
2. Zohreh Varasteh, Sarajo Mohanta, Stephanie Robu, Miriam Braeuer, Yuanfang Li, Negar Omidvari, Geoffrey Topping, Ting Sun, Stephan G. Nekolla, Antonia Richter, Christian Weber, Andreas Habenicht, Uwe A. Haberkorn, Wolfgang A. Weber. Molecular Imaging of Fibroblast Activity After Myocardial Infarction Using a 68Ga-Labeled Fibroblast Activation Protein Inhibitor, FAPI-04. Journal of Nuclear Medicine, 2019; 60 (12): 1743 DOI: 10.2967/jnumed.119.226993

Episode 359 - Life surviving on freezing planets, faint suns and meteorites

What can bacteria from an iron ore rich lake tell us about life on early earth? Have scientists finally solved a Carl Sagan paradox about life on early earth? When the earth was young, so was the sun, and that meant less light and heat. How did early life on earth survive if there was not enough sunlight to keep it warm? How did iron ore eating and secreting bacteria help lead to widespread life on our planet? How did micro organisms get enough oxygen to survive when the entire planet was frozen over? What can iron ore deposits tell us about life surviving when the entire planet was frozen over? Can life survive on a meteorite, the answer is surprising. How can a microbe be more suited to life on a meteorite than on earth?

1. Katharine J. Thompson, Paul A. Kenward, Kohen W. Bauer, Tyler Warchola, Tina Gauger, Raul Martinez, Rachel L. Simister, Céline C. Michiels, Marc Llirós, Christopher T. Reinhard, Andreas Kappler, Kurt O. Konhauser, Sean A. Crowe. Photoferrotrophy, deposition of banded iron formations, and methane production in Archean oceans. Science Advances, 2019; 5 (11): eaav2869 DOI: 10.1126/sciadv.aav2869
2. Maxwell A. Lechte, Malcolm W. Wallace, Ashleigh van Smeerdijk Hood, Weiqiang Li, Ganqing Jiang, Galen P. Halverson, Dan Asael, Stephanie L. McColl, Noah J. Planavsky. Subglacial meltwater supported aerobic marine habitats during Snowball Earth. Proceedings of the National Academy of Sciences, 2019; 201909165 DOI: 10.1073/pnas.1909165116
3. Tetyana Milojevic, Denise Kölbl, Ludovic Ferrière, Mihaela Albu, Adrienne Kish, Roberta L. Flemming, Christian Koeberl, Amir Blazevic, Ziga Zebec, Simon K.-M. R. Rittmann, Christa Schleper, Marc Pignitter, Veronika Somoza, Mario P. Schimak, Alexandra N. Rupert. Exploring the microbial biotransformation of extraterrestrial material on nanometer scale. Scientific Reports, 2019; 9 (1) DOI: 10.1038/s41598-019-54482-7

Episode 358 - Wildfires, climate change, smog and charcoal

As the climate changes, wildfires become more common and more dangerous. Smoke clouds from wildfires can linger for weeks, but what chemistry changes inside the smog? Aerosols amongst other particles lurk inside wildfire smoke. How do we study the changes in wildfire smoke; by flying planes through the plumes. How do wildfires impact the CO2 emissions of a region?  Can wildfires help store carbon through charcoal? What can charred biomass to do help capture carbon?

1. Kouji Adachi, Arthur J. Sedlacek, Lawrence Kleinman, Stephen R. Springston, Jian Wang, Duli Chand, John M. Hubbe, John E. Shilling, Timothy B. Onasch, Takeshi Kinase, Kohei Sakata, Yoshio Takahashi, Peter R. Buseck. Spherical tarball particles form through rapid chemical and physical changes of organic matter in biomass-burning smoke. Proceedings of the National Academy of Sciences, 2019; 201900129 DOI: 10.1073/pnas.1900129116
2. Matthew W. Jones, Cristina Santín, Guido R. van der Werf, Stefan H. Doerr. Global fire emissions buffered by the production of pyrogenic carbon. Nature Geoscience, 2019; DOI: 10.1038/s41561-019-0403-x

Episode 357 - Microbiology vs Macro climate challenges

Scientist are turning to microbiology to fight global climate challenges. How do you change a microbe from consumer to producer? Can you teach old e-coli new tricks, and make it consume CO2? How can a gut bacteria start to behave like a plant? Can we use enzymes to produce Hydrogen gas efficiently? What is the missing step in hydrogen fuel cell production? Can synthesised enzyme engines help us produce hydrogen without complex processes?

References:

1.   Gleizer et al. Conversion of Escherichia coli to Generate All Biomass Carbon from CO2. Cell, 2019 DOI: 10.1016/j.cell.2019.11.009
2. The binuclear cluster of [FeFe] hydrogenase is formed with sulfur donated by cysteine of an [Fe(Cys)(CO)2(CN)] organometallic precursor. Proceedings of the National Academy of Sciences, 2019; 116 (42): 20850 DOI: 10.1073/pnas.1913324116
    

Episode 356 - Responding to signs of danger

How do animals communicate information about danger? When a threat is detected by one animal, how do they pass it along to others? Does empathy play a role in how a create responds to a threat? Does the reaction of others around you change your response to threats? What chemical causes you to freeze in response to danger? How does serotonin cause deer in the headlights moments? What's the link between serotonin and slowing down in response to danger?

1. Yingying Han, Rune Bruls, Efe Soyman, Rajat Mani Thomas, Vasiliki Pentaraki, Naomi Jelinek, Mirjam Heinemans, Iege Bassez, Sam Verschooren, Illanah Pruis, Thijs Van Lierde, Nathaly Carrillo, Valeria Gazzola, Maria Carrillo, Christian Keysers. Bidirectional cingulate-dependent danger information transfer across rats. PLOS Biology, 2019; 17 (12): e3000524 DOI: 10.1371/journal.pbio.3000524
2. Clare E. Howard, Chin-Lin Chen, Tanya Tabachnik, Rick Hormigo, Pavan Ramdya, Richard S. Mann. Serotonergic Modulation of Walking in Drosophila. Current Biology, 2019; DOI: 10.1016/j.cub.2019.10.042

Episode 353 - Mysteries of plants, from using rare metals to boosting photosynthesis

Plants play an important role in our environment, yet there is still so much more to understand. We often think of nature as a zero sum game, but older and younger plants can collaborate. When surviving in a harsh environment, the best results occur when old and young plants grow together. Photosynthesis seems simple, but understanding the intricacies of the mechanisms can help us boost crop yields. Regulating the amount of photosynthesis can help plants survive or thrive in changing climates. How do boreal forests help capture nitrogen from the air? What does an odd metal have to do with forests in Canada storing nitrogen? 

1. Alicia Montesinos-Navarro, Isabelle Storer, Rocío Perez-Barrales. Benefits for nurse and facilitated plants emerge when interactions are considered along the entire life-span. Perspectives in Plant Ecology, Evolution and Systematics, 2019; 41: 125483 DOI: 10.1016/j.ppees.2019.125483
2. Lorna A. Malone, Pu Qian, Guy E. Mayneord, Andrew Hitchcock, David A. Farmer, Rebecca F. Thompson, David J. K. Swainsbury, Neil A. Ranson, C. Neil Hunter, Matthew P. Johnson. Cryo-EM structure of the spinach cytochrome b6 f complex at 3.6 Å resolution. Nature, 2019; DOI: 10.1038/s41586-019-1746-6
3. Princeton University. (2019, November 11). Nature's backup plan for converting nitrogen into plant nutrients. ScienceDaily. Retrieved November 15, 2019 from www.sciencedaily.com/releases/2019/11/191111180100.htm

Episode 352 - Figuring out where sound comes from and perceiving pitch

This week we look at the way our brains process sound, music, pitch and rhythm. How does our brain figure out where a sound is coming from? Do our eyes and ears process distance and location in a similar way? How does our brain discern differences in stimuli? What can we learn about pitch and rhythm from studying a remote Bolivian tribe? Is there a biological limit to our perception of sounds? Is our ability to perceive rhythm, chords and pitch cultural or biological?

References:

1. Antje Ihlefeld, Nima Alamatsaz, Robert M Shapley. Population rate-coding predicts correctly that human sound localization depends on sound intensity. eLife, 2019; 8 DOI: 10.7554/eLife.47027
2. Nori Jacoby, Eduardo A. Undurraga, Malinda J. McPherson, Joaquín Valdés, Tomás Ossandón, Josh H. McDermott. Universal and Non-universal Features of Musical Pitch Perception Revealed by Singing. Current Biology, 2019; DOI: 10.1016/j.cub.2019.08.020

Episode 349 - Domesticating fungus for our food

Humans have been using micro-organisms like fungus and bacteria to help improve our food for millennia. Can we tame new wild species of fungus to help create new types of our favourite foods like cheese? Penicillin is mostly known for antibiotics but it also helps give Camembert its particular taste. What causes cheese to rapidly tame wild strains of fungus? We are not the only ones who use microbes to help our food. Ants help stop disease from destroying plants by spreading their own antibiotics. Ant base antibiotics help stop plant pathogens. Sometimes bacteria don't fight against each other but rather team up and work together. Survival of kindest rules for bacteria, which helps different strains work together to survive.

References:

1. Bodinaku, I., Shaffer, J., Connors, A. B., Steenwyk, J. L., Biango-Daniels, M. N., Kastman, E. K., … Wolfe, B. E. (2019). Rapid Phenotypic and Metabolomic Domestication of Wild Penicillium Molds on Cheese. MBio, 10(5). doi: 10.1128/mbio.02445-19
2. Joachim Offenberg, Christian Damgaard. Ants suppressing plant pathogens: a review. Oikos, 2019; DOI: 10.1111/oik.06744
3. Wenzheng Liu, Samuel Jacquiod, Asker Brejnrod, Jakob Russel, Mette Burmølle, Søren J. Sørensen. Deciphering links between bacterial interactions and spatial organization in multispecies biofilms. The ISME Journal, 2019; DOI: 10.1038/s41396-019-0494-9

Episode 347 - Capturing carbon with better farms and forests

Capturing carbon is important for helping offset CO2 emissions and tackling climate changes. Farming has an important role to play in improving CO2 sequestration with the use of cover crops and compost. Forests are important carbon sinks too, but they are at risk releasing a lot of the trapped carbon if care is not taken to stop invasive species. Plus fertilisers have helped feed the planet but can leech out nitrogen into the environment, so how do we better manage and improve the nitrogen cycle.

1. Nicole E. Tautges, Jessica L. Chiartas, Amélie C. M. Gaudin, Anthony T. O'Geen, Israel Herrera, Kate M. Scow. Deep soil inventories reveal that impacts of cover crops and compost on soil carbon sequestration differ in surface and subsurface soils. Global Change Biology, 2019; DOI: 10.1111/gcb.14762
2. Songlin Fei, Randall S. Morin, Christopher M. Oswalt, Andrew M. Liebhold. Biomass losses resulting from insect and disease invasions in US forests. Proceedings of the National Academy of Sciences, 2019; 201820601 DOI: 10.1073/pnas.1820601116
3. Benjamin Z. Houlton, Maya Almaraz, Viney Aneja, Amy T. Austin, Edith Bai, Kenneth G. Cassman, Jana E. Compton, Eric A. Davidson, Jan Willem Erisman, James N. Galloway, Baojing Gu, Guolin Yao, Luiz A. Martinelli, Kate Scow, William H. Schlesinger, Thomas P. Tomich, Chao Wang, Xin Zhang. A World of Cobenefits: Solving the Global Nitrogen Challenge. Earth's Future, 2019; DOI: 10.1029/2019EF001222

Episode 346 - Can washing machines help stop microplastics in oceans and make hospitals safer

Washing machines can save a lot of time and help clean up mess, but they can also harm our health and environment. Which washing process is better for the environment - full an fast or empty and delicate? How do washing machines help fill our oceans with microplastics? What can be done to help stop washing machines contributing to the microplastics in our waterways? Which washing setting is best for your health? Cold and clean or warm and soapy? How did a normal washing machine cause havoc in a hospital? How can you multi-drug resistant pathogens spread through a washing machine? 

References:

1. American Society for Microbiology. (2019, September 27). Your energy-efficient washing machine could be harboring pathogens: Lower temperatures used in 'energy saver' washing machines may not be killing all pathogens. ScienceDaily. Retrieved September 29, 2019 from www.sciencedaily.com/releases/2019/09/190927135202.htm
2. Max R. Kelly, Neil J. Lant, Martyn Kurr, J. Grant Burgess. Importance of Water-Volume on the Release of Microplastic Fibers from Laundry. Environmental Science & Technology, 2019; DOI: 10.1021/acs.est.9b03022

Episode 345 - Overactive immune brain cells and brain cells failing to eat themselves

Is it possible to stop Alzheimer's in it's tracks? How does the formation of plaques on your brain cells lead to Alzheimer's. Does the your brain immune cells fighting back against plaques lead to Alzheimers? Amino acids in the brain tying themselves into knots, can lead to super strong sealed zippers forming which dry out proteins, damage neurons and eventually can lead to diseases like Alzheimer's. An enzyme missing a repair or two over 60 years can lead to build up of kinked amino acids chains which can lead to neuron-degenerative diseases. What causes a cell to eat itself? Well its actually a pretty healthy thing to do. If a brain cell doesn't eat itself at the right time, well it can lead to a whole bunch of diseases.

1. Rebeccah A. Warmack, David R. Boyer, Chih-Te Zee, Logan S. Richards, Michael R. Sawaya, Duilio Cascio, Tamir Gonen, David S. Eisenberg, Steven G. Clarke. Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11183-z
2. Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11674-z
3. Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11671-2

Episode 343 - The circadian rhythm of plants, and fighting back against fungus

Growing enough food to feed the planet is a challenge that will only get harder as the climate changes. So how do farmers and scientists work together to make crops more sustainable, more resilient to disease, and use less herbicides? With genetic engineering, one of the worlds most important crops, rice, can be made even tougher. Using a two type bait gene, rice can be engineered to fight off fungus like rice blast. If you have to spray with herbicides, when should you do it? Well you need to pay attention to the circadian rhythm of the plants.

1. Freya A Varden, Hiromasa Saitoh, Kae Yoshino, Marina Franceschetti, Sophien Kamoun, Ryohei Terauchi, Mark J. Banfield. Cross-reactivity of a rice NLR immune receptor to distinct effectors from the rice blast pathogen Magnaporthe oryzae provides partial disease resistance. Journal of Biological Chemistry, 2019; jbc.RA119.007730 DOI: 10.1074/jbc.RA119.007730
2. Fiona E. Belbin, Gavin J. Hall, Amelia B. Jackson, Florence E. Schanschieff, George Archibald, Carl Formstone, Antony N. Dodd. Plant circadian rhythms regulate the effectiveness of a glyphosate-based herbicide. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-019-11709-5

Episode 341 - Forming, Saving and preserving new memories

Your brain uses proteins synthesis and redundancy to help form and keep memories. Intricate biochemistry helps your neurons connect to each other to form new memories. Forming new memories is a sticky situation.  Keeping them stuck together over time in a long lasting memory relies on protein synthesis. Its important not just to have strong connections between neurons to form memories, you also need spares. By having redundancy and backups it means that you can still remember a key memory if one of those connections fails.

References

1. Lenzie Ford et al. CPEB3 inhibits translation of mRNA targets by localizing them to P bodies. PNAS, 2019 DOI: 10.1073/pnas.1815275116
2. Walter G. Gonzalez, Hanwen Zhang, Anna Harutyunyan, Carlos Lois. Persistence of neuronal representations through time and damage in the hippocampus. Science, 2019: Vol. 365, Issue 6455, pp. 821-825 DOI: 10.1126/science.aav9199