Lagrange Point

A change of seasons means you may be sniffling, sneezing and having teary eyes. So why do our bodies sometimes cause such an over the top response to pollen? We dive into the science behind hay fever, what histamine even does for you, and how it's helping you in more ways than you realise. Plus we find out what's being done to deliver a 1,2,3 blow to Traveller's Diarrhoea.

References:

1. Alessandra Misto, Gustavo Provensi, Valentina Vozella, Maria Beatrice Passani, Daniele Piomelli. Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.09.014
2. Caroline B.K. Mathiesen, Michael C. Carlsson, Stephanie Brand, Svenning Rune Möller, Manja Idorn, Per thor Straten, Anders E. Pedersen, Sally Dabelsteen, Adnan Halim, Peter Adler Würtzen, Jens Brimnes, Henrik Ipsen, Bent L. Petersen, Hans H. Wandall. Genetically engineered cell factories produce glycoengineered vaccines that target antigen-presenting cells and reduce antigen-specific T-cell reactivity. Journal of Allergy and Clinical Immunology, 2018; DOI: 10.1016/j.jaci.2018.07.030
3. Renee M. Laird, Zuchao Ma, Nelum Dorabawila, Brittany Pequegnat, Eman Omari, Yang Liu, Alexander C. Maue, Steven T. Poole, Milton Maciel, Kavyashree Satish, Christina L. Gariepy, Nina M. Schumack, Annette L. McVeigh, Frédéric Poly, Cheryl P. Ewing, Michael G. Prouty, Mario A. Monteiro, Stephen J. Savarino, Patricia Guerry. Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella. Vaccine, 2018; DOI: 10.1016/j.vaccine.2018.09.052

Exoplanets are home to some extremely out of this world chemistry. From raining diamonds, to gaseous iron and titanium, even to secret supplies of water. If we want to understand just how unique our place in the universe is, we can try and replicate the odd conditions of exoplanets right here on earth. 

References

1. Peter M. Celliers et al. Insulator-metal transition in dense fluid deuterium. Science, 2018 DOI: 10.1126/science.aat0970
2. Sergey S. Lobanov, Qiang Zhu, Nicholas Holtgrewe, Clemens Prescher, Vitali B. Prakapenka, Artem R. Oganov, Alexander F. Goncharov. Stable magnesium peroxide at high pressure. Scientific Reports, 2015; 5: 13582 DOI: 10.1038/srep13582
3. H. Jens Hoeijmakers, David Ehrenreich, Kevin Heng, Daniel Kitzmann, Simon L. Grimm, Romain Allart, Russell Deitrick, Aurélien Wyttenbach, Maria Oreshenko, Lorenzo Pino, Paul B. Rimmer, Emilio Molinari, Luca Di Fabrizio. Atomic iron and titanium in the atmosphere of the exoplanet KELT-9b. Nature, 2018; DOI: 10.1038/s41586-018-0401-y
4. Goldschmidt Conference. (2018, August 18). Water-worlds are common: Exoplanets may contain vast amounts of water. ScienceDaily. Retrieved August 18, 2018 from www.sciencedaily.com/releases/2018/08/180818115758.htm

How do you defend against invaders in a millenia long war? Well Koala DNA is currently using some ancient DNA weapons to fight back against a viral invader. We also find out about some unlikely alliances from different corals teaming up, to how bacteria manages to spread and colonize from place to place. All this and more this week on Lagrange Point. 

References:

1. Ulrike Löber, Matthew Hobbs, Anisha Dayaram, Kyriakos Tsangaras, Kiersten Jones, David E. Alquezar-Planas, Yasuko Ishida, Joanne Meers, Jens Mayer, Claudia Quedenau, Wei Chen, Rebecca N. Johnson, Peter Timms, Paul R. Young, Alfred L. Roca, Alex D. Greenwood. Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion. Proceedings of the National Academy of Sciences, 2018; 201807598 DOI: 10.1073/pnas.1807598115
2. Inês S. Pais, Rita S. Valente, Marta Sporniak, Luis Teixeira. Drosophila melanogaster establishes a species-specific mutualistic interaction with stable gut-colonizing bacteria. PLOS Biology, 2018; 16 (7): e2005710 DOI: 10.1371/journal.pbio.2005710
3. Luigi Musco, Tomás Vega Fernández, Erik Caroselli, John Murray Roberts, Fabio Badalamenti. Protocooperation among small polyps allows the coral Astroides calycularis to prey on large jellyfish. Ecology, 2018; DOI: 10.1002/ecy.2413

Keeping the world clean is a tricky job. You have to fight fatbergs, recycle large amounts of mess and even keep tanks of food clean. Fortunately material scientists keep inventing new methods, and re-applying old ones to help improve our planet. From using old mining techniques to recycle lithium ion batteries, to using oils to keep food equipment clean, plus tacking the monsters of the sewer - fatbergs.

REFERENCES

1. Ruiting Zhan, Zachary Oldenburg, Lei Pan. Recovery of active cathode materials from lithium-ion batteries using froth flotation. Sustainable Materials and Technologies, 2018; 17: e00062 DOI: 10.1016/j.susmat.2018.e00062
2. Tarek S. Awad, Dalal Asker, Benjamin D. Hatton. Food-Safe Modification of Stainless Steel Food-Processing Surfaces to Reduce Bacterial Biofilms. ACS Applied Materials & Interfaces, 2018; 10 (27): 22902 DOI: 10.1021/acsami.8b03788
3. Asha Srinivasan, Moutoshi Saha, Kit Caufield, Otman Abida, Ping Huang Liao, Kwang Victor Lo. Microwave-Enhanced Advanced Oxidation Treatment of Lipids and Food Wastes. Water, Air, & Soil Pollution, 2018; 229 (7) DOI: 10.1007/s11270-018-3894-y

Everyone knows about bacteria and viruses, but fungal infections can also wreak havoc with our health. Since we know so little about them, fighting back is difficult. But we can learn a lot but diving deep into the way fungal infections are structured, how they fight back and how they fight eachother. 

1. Xue Kang, Alex Kirui, Artur Muszyński, Malitha C. Dickwella Widanage, Adrian Chen, Parastoo Azadi, Ping Wang, Frederic Mentink-Vigier, Tuo Wang. Molecular architecture of fungal cell walls revealed by solid-state NMR. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-05199-0
2. Timothy M. Tucey, Jiyoti Verma, Paul F. Harrison, Sarah L. Snelgrove, Tricia L. Lo, Allison K. Scherer, Adele A. Barugahare, David R. Powell, Robert T. Wheeler, Michael J. Hickey, Traude H. Beilharz, Thomas Naderer, Ana Traven. Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection. Cell Metabolism, 2018; 27 (5): 988 DOI: 10.1016/j.cmet.2018.03.019
3. University of Wisconsin-Madison. (2018, May 22). A hidden world of communication, chemical warfare, beneath the soil. ScienceDaily. Retrieved July 21, 2018 from www.sciencedaily.com/releases/2018/05/180522082202.htm

We are often tantalized by the prospect of water on Mars, but thanks to a Teenage Satellite we have found lakes of water on Mars, just beneath the surface. Plus we find out where all that martian dust comes from and check in on everyone's favourite Comet, 67-p.

1. R. Orosei, S. E. Lauro, E. Pettinelli, A. Cicchetti, M. Coradini, B. Cosciotti, F. Di Paolo, E. Flamini, E. Mattei, M. Pajola, F. Soldovieri, M. Cartacci, F. Cassenti, A. Frigeri, S. Giuppi, R. Martufi, A. Masdea, G. Mitri, C. Nenna, R. Noschese, M. Restano, R. Seu. Radar evidence of subglacial liquid water on Mars. Science, 2018; eaar7268 DOI: 10.1126/science.aar7268
2. Horner, J. (2018, July 26). Discovered: A huge liquid water lake beneath the southern pole of Mars. Retrieved from http://theconversation.com/discovered-a-huge-liquid-water-lake-beneath-the-southern-pole-of-mars-100523
3. Lujendra Ojha, Kevin Lewis, Suniti Karunatillake, Mariek Schmidt. The Medusae Fossae Formation as the single largest source of dust on Mars. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-05291-5
4. K. L. Heritier, K. Altwegg, J.-J. Berthelier, A. Beth, C. M. Carr, J. De Keyser, A. I. Eriksson, S. A. Fuselier, M. Galand, T. I. Gombosi, P. Henri, F. L. Johansson, H. Nilsson, M. Rubin, C. Simon Wedlund, M. G. G. T. Taylor, E Vigren. On the origin of molecular oxygen in cometary comae. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-04972-5

Solar Panels keep getting better, but what if we could have solar power even when it's very overcast? Plus is there a way to make concrete greener and less carbon intensive? What if one of those solutions also helped take care of waste product from Coal Power Plants? We look at innovative green technologies this week in Lagrange Point. 

1. Joshua Shank, Emil A. Kadlec, Robert L. Jarecki, Andrew Starbuck, Stephen Howell, David W. Peters, Paul S. Davids. Power Generation from a Radiative Thermal Source Using a Large-Area Infrared Rectenna. Physical Review Applied, 2018; 9 (5) DOI: 10.1103/PhysRevApplied.9.054040
2. Sarvesh Kumar Srivastava, Przemyslaw Piwek, Sonal R. Ayakar, Arman Bonakdarpour, David P. Wilkinson, Vikramaditya G. Yadav. A Biogenic Photovoltaic Material. Small, 2018; 14 (26): 1800729 DOI: 10.1002/smll.201800729
3. Gang Xu, Jing Zhong, Xianming Shi. Influence of graphene oxide in a chemically activated fly ash. Fuel, 2018; 226: 644 DOI: 10.1016/j.fuel.2018.04.033
4. Sung Hoon Hwang, Rouzbeh Shahsavari. High calcium cementless fly ash binder with low environmental footprint: Optimum Taguchi design. Journal of the American Ceramic Society, 2018; DOI: 10.1111/jace.15873

How far would you go to find a treatment that helps you or a loved one suffering from a chronic condition? Is it worth the side effects or the pain of jumping through bureaucratic hoops? Is it worth risking the black market? Plus we find out ways to make precision medicine even more precise to rule out side effects. 

References:

1. Bell, F. (2017, March 01). Sick kids chosen as first patients to receive legal medicinal cannabis in Victoria. Retrieved from http://www.abc.net.au/news/2017-03-01/children-with-epilepsy-receive-legal-medicinal-cannabis-victoria/8313902
2. Dunstan, J. (2018, June 08). Dad defends medicinal cannabis program as kids drop out. Retrieved from http://www.abc.net.au/news/2018-06-08/victorian-medicinal-cannabis-trial-kids-drop-out/9848596
3. Medical Marijuana and Epilepsy. (n.d.). Retrieved from https://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treatment-approaches/medical-marijuana-and-epilepsy
4. Understanding Epilepsy. (n.d.). Retrieved from https://www.epilepsy.org.au/about-epilepsy/understanding-epilepsy/
5. Zafar, A. (2017, May 26). Cannabis compound shown to slash seizures in kids with rare form of epilepsy | CBC News. Retrieved from https://www.cbc.ca/news/health/dravet-syndrome-epilepsy-cbd-1.4130180
6. A. Suraev, N. Lintzeris, J. Stuart, R. C. Kevin, R. Blackburn, E. Richards, J. C. Arnold, C. Ireland, L. Todd, D. J. Allsop, I. S. McGregor. Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-28127-0
7. Lei Zhang, Peng Zhang, Guangfu Wang, Huaye Zhang, Yajun Zhang, Yilin Yu, Mingxu Zhang, Jian Xiao, Piero Crespo, Johannes W. Hell, Li Lin, Richard L. Huganir, J. Julius Zhu. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron, 2018; 98 (4): 783 DOI: 10.1016/j.neuron.2018.03.049

Everyone loves lasers! From science fiction to the military and even scientists in labs. This week we look at using lasers to solve some unusual problems. From something deceptively simple as how to describe a smell to the complexities of better data transmission over WiFi.

1. Sarah K. Scholten, Christopher Perrella, James D. Anstie, Richard T. White, Waddah Al-Ashwal, Nicolas Bourbeau Hébert, Jérôme Genest, Andre N. Luiten. Number-Density Measurements of CO2 in Real Time with an Optical Frequency Comb for High Accuracy and Precision. Physical Review Applied, 2018; 9 (5) DOI: 10.1103/PhysRevApplied.9.054043
2. Marco Piccardo, Dmitry Kazakov, Noah A. Rubin, Paul Chevalier, Yongrui Wang, Feng Xie, Kevin Lascola, Alexey Belyanin, Federico Capasso. Time-dependent population inversion gratings in laser frequency combs. Optica, 2018; 5 (4): 475 DOI: 10.1364/OPTICA.5.000475
3. Image: Extreme ultraviolet (EUV) frequency comb, : Baxley/JILA, 2012, www.nist.gov/pml/div689/euv_comb.cfm

Our brains are incredibly complex machines, running millions of calculations in no time at all. But how do these fantastic circuits work? If you follow AI and computer science you may have heard of a ''neural net'' style program which mimics how the brain learns, but really, how do the messages get passed between neurons along such networks? Does shape matter? Can we study individual pathways? What happens if you try and pulse the brain to give it a boost? We find out about neurons, their networks and more.

References:

1. Shotaro Yoshida, Midori Kato-Negishi, Shoji Takeuchi. Assembly and Connection of Micropatterned Single Neurons for Neuronal Network Formation. Micromachines, 2018; 9 (5): 235 DOI: 10.3390/mi9050235
2. Fong Kuan Wong, Kinga Bercsenyi, Varun Sreenivasan, Adrián Portalés, Marian Fernández-Otero, Oscar Marín. Pyramidal cell regulation of interneuron survival sculpts cortical networks. Nature, 2018; 557 (7707): 668 DOI: 10.1038/s41586-018-0139-6
3. Nicole C Swann, Coralie de Hemptinne, Margaret C Thompson, Svjetlana Miocinovic, Andrew M Miller, Ro’ee Gilron, Jill L Ostrem, Howard J Chizeck, Philip A Starr. Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing. Journal of Neural Engineering, 2018; 15 (4): 046006 DOI: 10.1088/1741-2552/aabc9b

Now that China has banned importing rubbish, we really have to find innovative new ways to clean up our mess. We look at new solutions from dissolving plastic in enzymes, to making new steel from scrap cars to zero-waste phones.

Making water safe to drink is a problem for the largest cities all the way down to the most remote of communities. We look at the challenges to making water safe to drink, and some innovative new research looking to make it easier to obtain safe drinking water.

This week we find out some strange and new ways scientists are hunting for a new weapons in the antimicrobial resistance arms race. Including turning to platypus milk for guidance, cooking the insides of bacteria like an egg and blocking it from even spreading. Plus we get an update on Mammal March Madness.

How can we make wounds close and heal by sticking together better? Is there some kind of super strong glues that can help stick even when wet? What can we learn from spiders to help heal a broken heart? All these bio materials and more in this week's episode.

How do we protect find and protect life across the universe from ourselves? What are the risks and dangers of sending bacteria out into the universe, and how can we prevent unwanted contamination.

How can we cut down on waste from everything coffee to packaging? What new materials, processes and technology can help us eliminate waste and recycle more? Are there ways to turn food waste into food valued added products?

Mysterious underwater caverns teeming with unusual life, and oceans trapped in time. We dive into the mysteries of oceans, caves and their hidden ecosystems.

Unexpected journeys in science from a link between quantum mechanics and proteins, to spider silk hearing aides. We hear how scientific research can start in one place and end far far away.

How can we make printers more realistic and life like? How can we push the limits of printing and make hidden messages cheaply and efficiently? How do we turn printed advertisements into productive energy efficient solar cells?

What lessons in resilience to fires, climate change, epidemics and sudden shocks from insects can be adapted to help humans adjust to change.