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3Episodes
Category: Science

A fun take on the latest science news with enough data to sink your teeth into. Lagrange Point goes beyond the glossy summary and gets in depth with the research from across the world.

Lagrange Point Episode 321 - Bacterial search engine, blending in with hosts

April 8, 2019

Bacteria are all around us and inside our guts too. Yet despite this there is still so much we do not know about them. We keep discovering new types, new species and then they change the game by blending into hosts and having new side effects. We look at how microbial infections disguise themselves to blend in, how fungal infections deactivate alarm systems, and just how many unknown bacteria there are in your gut. We also find out about ways to tackle our lack of knowledge with bacterial search engines.
References

  1. Alexandre Almeida, Alex L. Mitchell, Miguel Boland, Samuel C. Forster, Gregory B. Gloor, Aleksandra Tarkowska, Trevor D. Lawley, Robert D. Finn. A new genomic blueprint of the human gut microbiotaNature, 2019; DOI: 10.1038/s41586-019-0965-1
  2. Iratxe Estibariz, Annemarie Overmann, Florent Ailloud, Juliane Krebes, Christine Josenhans, Sebastian Suerbaum. The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pyloriNucleic Acids Research, 2019; DOI: 10.1093/nar/gky1307
  3. Koenig S et al. Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 HydrolaseCell Chemical Biology, 2019 DOI: 10.1016/j.chembiol.2019.01.001
  4. Phelim Bradley, Henk C. den Bakker, Eduardo P. C. Rocha, Gil McVean, Zamin Iqbal. Ultrafast search of all deposited bacterial and viral genomic dataNature Biotechnology, 2019; 37 (2): 152 DOI: 10.1038/s41587-018-0010-1